Component
D-Tyr-Val-NH2
Synthetic amidated product of D-Tyr-Val-Gly.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Bovine intermediate-pituitary granule amidation of D-Tyr-Val-Gly responded to ascorbate, with apparent substrate Km and Vmax changing as the ascorbate concentration changed.
Experimental context and source evidence
- cross_nutrient
- Vitamin C chemistry in collagen, modified-lysine/carnitine metabolism or copper-dependent peptide/catecholamine processing.
- experimental_model
- Bovine intermediate-pituitary secretory-granule kinetic assay
- exposure
- Synthetic D-Tyr-Val-Gly amidation with varied ascorbate, oxygen and divalent-metal chelators/copper.
- limitations
- The old granule preparation is not a purified modern PAM-domain assay; synthetic substrate kinetics do not quantify all hormone amidation.
- nutrient_topic
- Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
- organism
- Bos taurus
- plain_language
- Vitamin C helps the pituitary enzyme finish a peptide with an amide group.
- primary_references
- [pam1983] Identification in pituitary tissue of a peptide alpha-amidation activity that acts on glycine-extended peptides and requires molecular oxygen, copper, and ascorbic acid. (1983). https://pubmed.ncbi.nlm.nih.gov/6576381/ DOI: 10.1073/pnas.80.16.5144
- tissue_or_cell_type
- Pituitary secretory granules
Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 859–870
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Bovine intermediate-pituitary secretory-granule kinetic assay · source_derived_draft · unverified_draft
### vc-enzyme-bovine-amidation-ascorbate Bovine intermediate-pituitary granule amidation of D-Tyr-Val-Gly responded to ascorbate, with apparent substrate Km and Vmax changing as the ascorbate concentration changed. Condition category: normal nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: Vitamin C helps the pituitary enzyme finish a peptide with an amide group. organism: Bos taurus tissue_or_cell_type: Pituitary secretory granules experimental_model: Bovine intermediate-pituitary secretory-granule kinetic assay limitations: The old granule preparation is not a purified modern PAM-domain assay; synthetic substrate kinetics do not quantify all hormone amidation. cross_nutrient: Vitamin C chemistry in collagen, modified-lysine/carnitine metabolism or copper-dependent peptide/catecholamine processing. exposure: Synthetic D-Tyr-Val-Gly amidation with varied ascorbate, oxygen and divalent-metal chelators/copper. [pam1983] Identification in pituitary tissue of a peptide alpha-amidation activity that acts on glycine-extended peptides and requires molecular oxygen, copper, and ascorbic acid. (1983). https://pubmed.ncbi.nlm.nih.gov/6576381/ DOI: 10.1073/pnas.80.16.5144
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.