Component
CB1 receptor downregulation
CB1 receptor downregulation. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
CB1 receptors and related molecular elements of the endocannabinoid system were downregulated in epileptic human hippocampus.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/thc-research/18354002.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "20b254a1e7d4462dcad993b76e889a26d729d604c71e2456c2d13a2a1420c728", "start_char": 0, "end_char": 2055, "text_sha256": "20b254a1e7d4462dcad993b76e889a26d729d604c71e2456c2d13a2a1420c728"}
- experimental_model
- Post-mortem and surgical human hippocampal tissue from epilepsy
- exposure
- Measurement of CB1 and endocannabinoid system elements in epileptic tissue
- limitations
- A human tissue measurement, but in diseased tissue where the disease itself may drive the change. It is not a measurement of cannabis users.
- nutrient_topic
- THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
- organism
- Human
- plain_language
- In diseased human hippocampus the whole system is turned down, receptor included.
- primary_references
- [thc-p18354002] Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus. (2008). https://pubmed.ncbi.nlm.nih.gov/18354002/ DOI: 10.1523/jneurosci.4465-07.2008
- tissue_or_cell_type
- Hippocampus
THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 231–242
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Post-mortem and surgical human hippocampal tissue from epilepsy · source_derived_draft · unverified_draft
### thc-cb1-downregulation-human CB1 receptors and related molecular elements of the endocannabinoid system were downregulated in epileptic human hippocampus. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: In diseased human hippocampus the whole system is turned down, receptor included. organism: Human tissue_or_cell_type: Hippocampus experimental_model: Post-mortem and surgical human hippocampal tissue from epilepsy limitations: A human tissue measurement, but in diseased tissue where the disease itself may drive the change. It is not a measurement of cannabis users. exposure: Measurement of CB1 and endocannabinoid system elements in epileptic tissue evidence_span: {"source_cache": "artifacts/thc-research/18354002.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "20b254a1e7d4462dcad993b76e889a26d729d604c71e2456c2d13a2a1420c728", "start_char": 0, "end_char": 2055, "text_sha256": "20b254a1e7d4462dcad993b76e889a26d729d604c71e2456c2d13a2a1420c728"} [thc-p18354002] Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus. (2008). https://pubmed.ncbi.nlm.nih.gov/18354002/ DOI: 10.1523/jneurosci.4465-07.2008
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.