Component
Caloric intake
Caloric intake. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Compared with high-fat-diet mice given isocaloric soybean oil, 8-methyl nonanoic acid feeding reduced caloric intake and body weight gain in diet-induced obese mice in association with weight loss in several tissues and organs and transcriptional downregulation of the orexigenic agouti-related protein in the hypothalamus, and despite no improvement in glucose or insulin tolerance tests it delayed the onset of high-fat-diet-induced insulin resistance during the early experimental period.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/dihydrocapsaicin-research/40827132.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ec9a287d601f180f392c2944bd9bf509dbc0f27924ec10143aa9a2a5bc77b817", "start_char": 0, "end_char": 1954, "text_sha256": "ec9a287d601f180f392c2944bd9bf509dbc0f27924ec10143aa9a2a5bc77b817"}
- experimental_model
- C57BL/6NJcl mice fed for 18 weeks with glucose and insulin tolerance testing
- exposure
- High-fat diet supplemented with triacylglycerols consisting of 8-methyl nonanoic acid or isocaloric soybean oil
- limitations
- Tests the metabolite rather than the parent compound, over a long feeding period, and reports a clear negative alongside the positives. 8-methyl nonanoic acid is non-pungent.
- nutrient_topic
- Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin
- organism
- Mouse
- plain_language
- The fragment left when the molecule is cut apart slows weight gain and delays insulin resistance, without improving the glucose tests.
- primary_references
- [dhc-p40827132] Effect of 8-Methyl Nonanoic Acid, a Degradation By-Product of Dihydrocapsaicin, on Energy and Glucose Homeostasis in Diet-Induced Obese Mice. (2025). https://pubmed.ncbi.nlm.nih.gov/40827132/ DOI: 10.2147/jep.s536185
- tissue_or_cell_type
- Whole body, hypothalamus and adipose tissue
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · C57BL/6NJcl mice fed for 18 weeks with glucose and insulin tolerance testing · source_derived_draft · unverified_draft
### dhc-8-mna-slows-metabolic-syndrome Compared with high-fat-diet mice given isocaloric soybean oil, 8-methyl nonanoic acid feeding reduced caloric intake and body weight gain in diet-induced obese mice in association with weight loss in several tissues and organs and transcriptional downregulation of the orexigenic agouti-related protein in the hypothalamus, and despite no improvement in glucose or insulin tolerance tests it delayed the onset of high-fat-diet-induced insulin resistance during the early experimental period. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: The fragment left when the molecule is cut apart slows weight gain and delays insulin resistance, without improving the glucose tests. organism: Mouse tissue_or_cell_type: Whole body, hypothalamus and adipose tissue experimental_model: C57BL/6NJcl mice fed for 18 weeks with glucose and insulin tolerance testing limitations: Tests the metabolite rather than the parent compound, over a long feeding period, and reports a clear negative alongside the positives. 8-methyl nonanoic acid is non-pungent. exposure: High-fat diet supplemented with triacylglycerols consisting of 8-methyl nonanoic acid or isocaloric soybean oil evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/40827132.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ec9a287d601f180f392c2944bd9bf509dbc0f27924ec10143aa9a2a5bc77b817", "start_char": 0, "end_char": 1954, "text_sha256": "ec9a287d601f180f392c2944bd9bf509dbc0f27924ec10143aa9a2a5bc77b817"} [dhc-p40827132] Effect of 8-Methyl Nonanoic Acid, a Degradation By-Product of Dihydrocapsaicin, on Energy and Glucose Homeostasis in Diet-Induced Obese Mice. (2025). https://pubmed.ncbi.nlm.nih.gov/40827132/ DOI: 10.2147/jep.s536185
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.