Component
Blood manganese concentration (specimen not further specified)
Blood manganese concentration (specimen not further specified). Read the linked claim for experimental scope.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
The genetic investigation linked SLC39A8 variants, very low blood manganese and type II glycosylation abnormalities.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- Human ZIP8 (SLC39A8) (affected_protein); Blood manganese concentration (specimen not further specified) (low_marker); UDP-galactose (related_substrate)
- evidence_span
- {"source_cache": "artifacts/manganese-clinical-sources/park2015.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "c4e7009c947d1854370f8c9f62c206a8c2190b2e23099a5b991b01465321023d", "start_char": 0, "end_char": 1348, "text_sha256": "c4e7009c947d1854370f8c9f62c206a8c2190b2e23099a5b991b01465321023d", "text_characters": 1348}
- experimental_model
- Genetic investigation of two individuals with SLC39A8-CDG
- exposure
- Affected individuals with compound heterozygous SLC39A8 variants.
- limitations
- Inherited transport failure is distinct from dietary shortage. The study supports hypogalactosylation but does not directly measure activity of every manganese enzyme in every tissue.
- nutrient_topic
- Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
- organism
- Homo sapiens
- plain_language
- A transport defect can deprive sugar-building enzymes of manganese.
- primary_references
- [mn-clin-park2015] SLC39A8 Deficiency: A Disorder of Manganese Transport and Glycosylation. (2015). https://pubmed.ncbi.nlm.nih.gov/26637979/ DOI: 10.1016/j.ajhg.2015.11.003
- tissue_or_cell_type
- Blood manganese and serum glycoproteins
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1174–1186
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Genetic investigation of two individuals with SLC39A8-CDG · source_derived_draft · unverified_draft
### mn-clin-zip8-glycosylation The genetic investigation linked SLC39A8 variants, very low blood manganese and type II glycosylation abnormalities. Condition category: machinery_impairment nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: A transport defect can deprive sugar-building enzymes of manganese. organism: Homo sapiens tissue_or_cell_type: Blood manganese and serum glycoproteins experimental_model: Genetic investigation of two individuals with SLC39A8-CDG limitations: Inherited transport failure is distinct from dietary shortage. The study supports hypogalactosylation but does not directly measure activity of every manganese enzyme in every tissue. exposure: Affected individuals with compound heterozygous SLC39A8 variants. cross_nutrient: Human ZIP8 (SLC39A8) (affected_protein); Blood manganese concentration (specimen not further specified) (low_marker); UDP-galactose (related_substrate) evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/park2015.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "c4e7009c947d1854370f8c9f62c206a8c2190b2e23099a5b991b01465321023d", "start_char": 0, "end_char": 1348, "text_sha256": "c4e7009c947d1854370f8c9f62c206a8c2190b2e23099a5b991b01465321023d", "text_characters": 1348} [mn-clin-park2015] SLC39A8 Deficiency: A Disorder of Manganese Transport and Glycosylation. (2015). https://pubmed.ncbi.nlm.nih.gov/26637979/ DOI: 10.1016/j.ajhg.2015.11.003
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.