Component
Secretory pathway calcium/manganese ATPase 1
Secretory pathway calcium/manganese ATPase 1. Experimental scope belongs to each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Human SPCA1a couples its ATPase cycle to manganese movement from cytosol into the Golgi lumen.
Experimental context and source evidence
- cross_nutrient
- Secretory pathway calcium/manganese ATPase 1 (parent_protein); Manganese(II) ion (transported_ion); Adenosine triphosphate (energy_substrate); Golgi apparatus (destination)
- evidence_span
- {"source_cache": "artifacts/manganese-glycosylation-sources/spca2023.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "06a3eac4cc4e989b9195bdb14847c868ddaa68935a12f2d5c5f50a1a47259fb8", "start_char": 0, "end_char": 1276, "text_sha256": "06a3eac4cc4e989b9195bdb14847c868ddaa68935a12f2d5c5f50a1a47259fb8", "text_characters": 1276}
- experimental_model
- Cryo-EM of purified human SPCA1a with ATP and divalent ions
- exposure
- ATP/Ca2+, ATP/Mn2+ and phosphorylated metal-free structural states.
- limitations
- Structural states explain the transport cycle but do not supply a dietary requirement or prove that calcium supplementation impairs manganese delivery.
- nutrient_topic
- Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
- organism
- Homo sapiens
- plain_language
- An ATP-powered pump delivers manganese to the Golgi.
- primary_references
- [mn-gly-spca2023] Cryo-EM structures of human SPCA1a reveal the mechanism of Ca<sup>2+</sup>/Mn<sup>2+</sup> transport into the Golgi apparatus. (2023). https://pubmed.ncbi.nlm.nih.gov/36867705/ DOI: 10.1126/sciadv.add9742
- tissue_or_cell_type
- Golgi membrane transport protein
- transport_effect
- raises Recorded as manganese movement from cytosol into the Golgi lumen.
- transport_pool
- the Golgi lumen Recorded as manganese movement from cytosol into the Golgi lumen.
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 698–710
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cryo-EM of purified human SPCA1a with ATP and divalent ions · source_derived_draft · unverified_draft
### mn-gly-spca-manganese Human SPCA1a couples its ATPase cycle to manganese movement from cytosol into the Golgi lumen. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: An ATP-powered pump delivers manganese to the Golgi. organism: Homo sapiens tissue_or_cell_type: Golgi membrane transport protein experimental_model: Cryo-EM of purified human SPCA1a with ATP and divalent ions limitations: Structural states explain the transport cycle but do not supply a dietary requirement or prove that calcium supplementation impairs manganese delivery. exposure: ATP/Ca2+, ATP/Mn2+ and phosphorylated metal-free structural states. cross_nutrient: Secretory pathway calcium/manganese ATPase 1 (parent_protein); Manganese(II) ion (transported_ion); Adenosine triphosphate (energy_substrate); Golgi apparatus (destination) evidence_span: {"source_cache": "artifacts/manganese-glycosylation-sources/spca2023.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "06a3eac4cc4e989b9195bdb14847c868ddaa68935a12f2d5c5f50a1a47259fb8", "start_char": 0, "end_char": 1276, "text_sha256": "06a3eac4cc4e989b9195bdb14847c868ddaa68935a12f2d5c5f50a1a47259fb8", "text_characters": 1276} [mn-gly-spca2023] Cryo-EM structures of human SPCA1a reveal the mechanism of Ca<sup>2+</sup>/Mn<sup>2+</sup> transport into the Golgi apparatus. (2023). https://pubmed.ncbi.nlm.nih.gov/36867705/ DOI: 10.1126/sciadv.add9742
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.