Component
Anxiety-related and depression-related behaviour in mice
Anxiety-related and depression-related behaviour in mice. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Chronic treatment with L. rhamnosus JB-1 induced region-dependent alterations in GABA-B1b messenger RNA in the brain with increases in cortical regions and concomitant reductions in expression in the hippocampus, amygdala and locus coeruleus compared with control-fed mice, the strain reduced stress-induced corticosterone and anxiety- and depression-related behavior, and the neurochemical and behavioral effects were not found in vagotomized mice, identifying the vagus as a major modulatory constitutive communication pathway between the bacteria exposed to the gut and the brain.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/gaba-research/21876150.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0008d58bc1bdc0cafce716c1ec3bf74e4bb7a74df49ccec93dafe087aee1183f", "start_char": 0, "end_char": 1706, "text_sha256": "0008d58bc1bdc0cafce716c1ec3bf74e4bb7a74df49ccec93dafe087aee1183f"}
- experimental_model
- Chronic feeding of a single bacterial strain with regional brain receptor expression, behaviour and vagotomy
- exposure
- Chronic Lactobacillus rhamnosus JB-1 in normal healthy mice, with and without vagotomy
- limitations
- The vagotomy arm is what localises the route. It is a single strain in one mouse background, and the receptor changes are messenger RNA rather than protein.
- nutrient_topic
- GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in. · Gamma-aminobutyric acid
- organism
- Mouse
- plain_language
- Feeding one bacterium changed behaviour and brain receptors, and cutting the nerve from gut to brain abolished it.
- primary_references
- [gb-p21876150] Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. (2011). https://pubmed.ncbi.nlm.nih.gov/21876150/ DOI: 10.1073/pnas.1102999108
- tissue_or_cell_type
- Brain, gut and vagus nerve
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Chronic feeding of a single bacterial strain with regional brain receptor expression, behaviour and vagotomy · source_derived_draft · unverified_draft
### gb-the-effect-travels-by-nerve Chronic treatment with L. rhamnosus JB-1 induced region-dependent alterations in GABA-B1b messenger RNA in the brain with increases in cortical regions and concomitant reductions in expression in the hippocampus, amygdala and locus coeruleus compared with control-fed mice, the strain reduced stress-induced corticosterone and anxiety- and depression-related behavior, and the neurochemical and behavioral effects were not found in vagotomized mice, identifying the vagus as a major modulatory constitutive communication pathway between the bacteria exposed to the gut and the brain. Condition category: normal nutrient_topic: GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in. plain_language: Feeding one bacterium changed behaviour and brain receptors, and cutting the nerve from gut to brain abolished it. organism: Mouse tissue_or_cell_type: Brain, gut and vagus nerve experimental_model: Chronic feeding of a single bacterial strain with regional brain receptor expression, behaviour and vagotomy limitations: The vagotomy arm is what localises the route. It is a single strain in one mouse background, and the receptor changes are messenger RNA rather than protein. exposure: Chronic Lactobacillus rhamnosus JB-1 in normal healthy mice, with and without vagotomy evidence_span: {"source_cache": "artifacts/gaba-research/21876150.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0008d58bc1bdc0cafce716c1ec3bf74e4bb7a74df49ccec93dafe087aee1183f", "start_char": 0, "end_char": 1706, "text_sha256": "0008d58bc1bdc0cafce716c1ec3bf74e4bb7a74df49ccec93dafe087aee1183f"} [gb-p21876150] Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. (2011). https://pubmed.ncbi.nlm.nih.gov/21876150/ DOI: 10.1073/pnas.1102999108
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.