Component

Agouti-related protein / AgRP, an orexigenic neuropeptide

Agouti-related protein / AgRP, an orexigenic neuropeptide. Species, exposure and limitations are retained in each linked claim.

1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

  1. Compared with high-fat-diet mice given isocaloric soybean oil, 8-methyl nonanoic acid feeding reduced caloric intake and body weight gain in diet-induced obese mice in association with weight loss in several tissues and organs and transcriptional downregulation of the orexigenic agouti-related protein in the hypothalamus, and despite no improvement in glucose or insulin tolerance tests it delayed the onset of high-fat-diet-induced insulin resistance during the early experimental period.

    8-methyl nonanoic acid, the methyl-branched medium-chain fatty acid released from dihydrocapsaicin → Diet-induced obesity in mice on a high-fat diet source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/dihydrocapsaicin-research/40827132.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ec9a287d601f180f392c2944bd9bf509dbc0f27924ec10143aa9a2a5bc77b817", "start_char": 0, "end_char": 1954, "text_sha256": "ec9a287d601f180f392c2944bd9bf509dbc0f27924ec10143aa9a2a5bc77b817"}
    experimental_model
    C57BL/6NJcl mice fed for 18 weeks with glucose and insulin tolerance testing
    exposure
    High-fat diet supplemented with triacylglycerols consisting of 8-methyl nonanoic acid or isocaloric soybean oil
    limitations
    Tests the metabolite rather than the parent compound, over a long feeding period, and reports a clear negative alongside the positives. 8-methyl nonanoic acid is non-pungent.
    nutrient_topic
    Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin
    organism
    Mouse
    plain_language
    The fragment left when the molecule is cut apart slows weight gain and delays insulin resistance, without improving the glucose tests.
    primary_references
    [dhc-p40827132] Effect of 8-Methyl Nonanoic Acid, a Degradation By-Product of Dihydrocapsaicin, on Energy and Glucose Homeostasis in Diet-Induced Obese Mice. (2025). https://pubmed.ncbi.nlm.nih.gov/40827132/ DOI: 10.2147/jep.s536185
    tissue_or_cell_type
    Whole body, hypothalamus and adipose tissue

    Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21) · lines 608–619

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · C57BL/6NJcl mice fed for 18 weeks with glucose and insulin tolerance testing · source_derived_draft · unverified_draft

    ### dhc-8-mna-slows-metabolic-syndrome Compared with high-fat-diet mice given isocaloric soybean oil, 8-methyl nonanoic acid feeding reduced caloric intake and body weight gain in diet-induced obese mice in association with weight loss in several tissues and organs and transcriptional downregulation of the orexigenic agouti-related protein in the hypothalamus, and despite no improvement in glucose or insulin tolerance tests it delayed the onset of high-fat-diet-induced insulin resistance during the early experimental period. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: The fragment left when the molecule is cut apart slows weight gain and delays insulin resistance, without improving the glucose tests. organism: Mouse tissue_or_cell_type: Whole body, hypothalamus and adipose tissue experimental_model: C57BL/6NJcl mice fed for 18 weeks with glucose and insulin tolerance testing limitations: Tests the metabolite rather than the parent compound, over a long feeding period, and reports a clear negative alongside the positives. 8-methyl nonanoic acid is non-pungent. exposure: High-fat diet supplemented with triacylglycerols consisting of 8-methyl nonanoic acid or isocaloric soybean oil evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/40827132.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ec9a287d601f180f392c2944bd9bf509dbc0f27924ec10143aa9a2a5bc77b817", "start_char": 0, "end_char": 1954, "text_sha256": "ec9a287d601f180f392c2944bd9bf509dbc0f27924ec10143aa9a2a5bc77b817"} [dhc-p40827132] Effect of 8-Methyl Nonanoic Acid, a Degradation By-Product of Dihydrocapsaicin, on Energy and Glucose Homeostasis in Diet-Induced Obese Mice. (2025). https://pubmed.ncbi.nlm.nih.gov/40827132/ DOI: 10.2147/jep.s536185
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards