{"id":"ffee1281-6e04-5c53-91c0-cc13e9ee3dda","stable_key":"c94a9824-35fb-523c-b421-dc7341218dcb:indicaxanthin-human-fruit-icf","predicate":"associated_with_increase","statement":"Yellow-cactus-pear consumption was associated with increased motor-cortex intracortical facilitation in the preliminary human study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"c850fd22-990b-585e-ae38-60200bcc811c","mechanism_event_label":"Yellow-cactus-pear consumption was associated with increased motor-cortex intracortical facilitation in the preliminary human study.","subject":{"id":"c8b229b8-496f-55a0-8b58-f1f950d42e68","slug":"cactus-pear-2022-neurostimulation-meal","display_name":"Cactus pear fruit meal in the 2022 neurostimulation study","entity_type_key":"small_molecule"},"object":{"id":"b1fc77ce-c8b9-55ea-b740-a7b294c39136","slug":"human-motor-cortex-intracortical-facilitation","display_name":"Human motor-cortex intracortical facilitation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c850fd22-990b-585e-ae38-60200bcc811c","stable_key":"c94a9824-35fb-523c-b421-dc7341218dcb:indicaxanthin-human-fruit-icf-event","event_type":"observed_relationship","label":"Yellow-cactus-pear consumption was associated with increased motor-cortex intracortical facilitation in the preliminary human study.","description":"Yellow-cactus-pear consumption was associated with increased motor-cortex intracortical facilitation in the preliminary human study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c8b229b8-496f-55a0-8b58-f1f950d42e68","slug":"cactus-pear-2022-neurostimulation-meal","display_name":"Cactus pear fruit meal in the 2022 neurostimulation study","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b1fc77ce-c8b9-55ea-b740-a7b294c39136","slug":"human-motor-cortex-intracortical-facilitation","display_name":"Human motor-cortex intracortical facilitation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f2a6e469-05f0-5596-9054-da926389f584","slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"400 g yellow cactus pear fruit versus white-fruit comparator; exact indicaxanthin amount unresolved","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"90 min after fruit; sessions separated by at least one week","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary open full text, relevant results/methods and PubMed metadata.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Small healthy-male neurostimulation study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Whole-food single-blind preliminary study. Methods report 12 fruit/8 comparator participants and four comparator exclusions; participant accounting and fruit-color wording have inconsistencies. No isolated-compound efficacy or cognitive benefit was demonstrated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Dedicated indicaxanthin chapter; original betalain family identity and shared claims preserved.","comparator":null,"unit":null,"notes":"","entity":{"slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Small healthy-male neurostimulation study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Yellow-cactus-pear consumption was associated with increased motor-cortex intracortical facilitation in the preliminary human study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Modulation of Human Motor Cortical Excitability and Plasticity by Opuntia Ficus Indica Fruit Consumption: Evidence from a Preliminary Study through Non-Invasive Brain Stimulation. (2022). https://pubmed.ncbi.nlm.nih.gov/36432601/ DOI: 10.3390/nu14224915","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral whole fruit","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Primary motor cortex","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"33632c77-d1ff-5538-be01-25cf9a769c85","evidence_kind":"source_excerpt","locator":"Lines 261-270","start_line":261,"end_line":270,"excerpt":"## indicaxanthin-human-fruit-icf\nYellow-cactus-pear consumption was associated with increased motor-cortex intracortical facilitation in the preliminary human study.\nModel/species: Small healthy-male neurostimulation study\nTissue: Primary motor cortex\nExposure: 400 g yellow cactus pear fruit versus white-fruit comparator; exact indicaxanthin amount unresolved\nRoute: Oral whole fruit\nDuration: 90 min after fruit; sessions separated by at least one week\nLimits: Whole-food single-blind preliminary study. Methods report 12 fruit/8 comparator participants and four comparator exclusions; participant accounting and fruit-color wording have inconsistencies. No isolated-compound efficacy or cognitive benefit was demonstrated.\nPrimary reference: Modulation of Human Motor Cortical Excitability and Plasticity by Opuntia Ficus Indica Fruit Consumption: Evidence from a Preliminary Study through Non-Invasive Brain Stimulation. (2022). https://pubmed.ncbi.nlm.nih.gov/36432601/ DOI: 10.3390/nu14224915\nAccess: Primary open full text, relevant results/methods and PubMed metadata.","model_system":"Small healthy-male neurostimulation study","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived curation span; original paraphrase with primary citation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"18b7303c-98b7-54cb-ae8e-a8c6257657b1","stable_key":"import-c94a9824-35fb-523c-b421-dc7341218dcb","title":"Indicaxanthin: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of thirteen additional primary studies, with twenty-six existing claims from eight studies linked unchanged. Study-specific citations and limitations retained. Not publisher full text.","file_path":"","sha256":"fd5e7b3a108073af5a8cad0e226a483ae2cda3b0e1daed387553ee441acecd5f","revision_id":"f3357c22-1be7-5502-b4f5-415d19c3cf5a","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}