{"id":"ffd2a8f2-b61a-5ef3-9c53-27d0bdf3f35b","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-crc-other-markers-null","predicate":"has_unconfirmed_between_group_effect","statement":"Only IL-8 showed a significant between-group change; within-group decreases in hs-CRP and MMP-7 did not establish placebo-controlled benefits.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"4e6192b5-8a14-55a1-9bab-b99adf485170","mechanism_event_label":"Within-group improvement is not the same as a treatment effect.","subject":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"object":{"id":"4c8b5b93-d3f6-5062-b317-5bdec1be02e4","slug":"human-crc-fisetin-other-inflammatory-markers","display_name":"Other plasma markers in the fisetin colorectal-cancer trial","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4e6192b5-8a14-55a1-9bab-b99adf485170","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-crc-other-markers-null-event","event_type":"observed_relationship","label":"Within-group improvement is not the same as a treatment effect.","description":"Only IL-8 showed a significant between-group change; within-group decreases in hs-CRP and MMP-7 did not establish placebo-controlled benefits.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4c8b5b93-d3f6-5062-b317-5bdec1be02e4","slug":"human-crc-fisetin-other-inflammatory-markers","display_name":"Other plasma markers in the fisetin colorectal-cancer trial","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same 37-person trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Retains the negative comparison rather than promoting all measured trends.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Within-group improvement is not the same as a treatment effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29541713/ · DOI 10.1039/c7fo01898c","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"195c5179-0b1c-5f8a-9147-c3406e57f5ff","evidence_kind":"source_excerpt","locator":"Lines 512-518","start_line":512,"end_line":518,"excerpt":"## fisetin-crc-other-markers-null\nWithin-group improvement is not the same as a treatment effect.\nOnly IL-8 showed a significant between-group change; within-group decreases in hs-CRP and MMP-7 did not establish placebo-controlled benefits.\nModel: Same 37-person trial.\nLimitations: Retains the negative comparison rather than promoting all measured trends.\nEvidence access: Primary abstract\nEffect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29541713/ · DOI 10.1039/c7fo01898c","model_system":"Same 37-person trial.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1108bfff-6504-5152-a51f-ff3d7c27c282","stable_key":"import-74ef5bba-ee14-531c-b1bf-d1f297c56bb6","title":"Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c30e0764cd34bd062cfcbfaf32357ef29dfda30e7d4153c545178140f5054e09","revision_id":"40ff52c0-f4b9-5820-8abb-ff002c6364a4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}