{"id":"ffc24eab-ec1d-50c7-89e8-a0c2b7247b85","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-barrier-null","predicate":"did_not_significantly_change","statement":"Measured gastroduodenal, small-intestinal, colonic and whole-gut permeability did not improve significantly.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7e22dc0f-59e2-579b-bedb-4e0112e5e2fa","mechanism_event_label":"The trial did not show improved measured gut permeability.","subject":{"id":"5a68dbc7-8a64-51ab-aa81-acc113c5c2dd","slug":"sugar-beet-pectin","display_name":"Sugar beet pectin","entity_type_key":"chemical_species"},"object":{"id":"885db0c0-21e2-5751-9718-70f870ea2fa9","slug":"intestinal-permeability-probes","display_name":"Human intestinal permeability measured by sugar probes","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7e22dc0f-59e2-579b-bedb-4e0112e5e2fa","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-barrier-null-event","event_type":"observed_intervention","label":"The trial did not show improved measured gut permeability.","description":"Measured gastroduodenal, small-intestinal, colonic and whole-gut permeability did not improve significantly.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5a68dbc7-8a64-51ab-aa81-acc113c5c2dd","slug":"sugar-beet-pectin","display_name":"Sugar beet pectin","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"885db0c0-21e2-5751-9718-70f870ea2fa9","slug":"intestinal-permeability-probes","display_name":"Human intestinal permeability measured by sugar probes","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/pectin-research/31324040.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4794205aa64876bf788ee1195c9a68a69c3090a0d334eaf6fc2dbf201c02858e\", \"start_char\": 0, \"end_char\": 1425, \"text_sha256\": \"4794205aa64876bf788ee1195c9a68a69c3090a0d334eaf6fc2dbf201c02858e\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized controlled feeding; 52 young and 48 older adults enrolled","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"15 g/day pectin versus placebo for four weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Same intervention cohort as PMID31547291; healthy baseline participants. A null result here does not settle disease-specific effects.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pectin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pectin","display_name":"Pectin, structurally heterogeneous plant polysaccharides","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The trial did not show improved measured gut permeability.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[pectin-p31324040] The Impact of Pectin Supplementation on Intestinal Barrier Function in Healthy Young Adults and Healthy Elderly. (2019). https://pubmed.ncbi.nlm.nih.gov/31324040/ DOI: 10.3390/nu11071554","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestinal sugar permeability probes and colonic biopsies","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"dd036f8c-0c26-5162-bf61-0fbdc263a411","evidence_kind":"source_excerpt","locator":"Lines 1023-1034","start_line":1023,"end_line":1034,"excerpt":"### pectin-barrier-null\nMeasured gastroduodenal, small-intestinal, colonic and whole-gut permeability did not improve significantly.\nCondition category: normal\nnutrient_topic: Pectin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The trial did not show improved measured gut permeability.\norganism: Homo sapiens\ntissue_or_cell_type: Intestinal sugar permeability probes and colonic biopsies\nexperimental_model: Randomized controlled feeding; 52 young and 48 older adults enrolled\nlimitations: Same intervention cohort as PMID31547291; healthy baseline participants. A null result here does not settle disease-specific effects.\nexposure: 15 g/day pectin versus placebo for four weeks\nevidence_span: {\"source_cache\": \"artifacts/pectin-research/31324040.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4794205aa64876bf788ee1195c9a68a69c3090a0d334eaf6fc2dbf201c02858e\", \"start_char\": 0, \"end_char\": 1425, \"text_sha256\": \"4794205aa64876bf788ee1195c9a68a69c3090a0d334eaf6fc2dbf201c02858e\"}\n[pectin-p31324040] The Impact of Pectin Supplementation on Intestinal Barrier Function in Healthy Young Adults and Healthy Elderly. (2019). https://pubmed.ncbi.nlm.nih.gov/31324040/ DOI: 10.3390/nu11071554","model_system":"Randomized controlled feeding; 52 young and 48 older adults enrolled","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [pectin-p31324040] The Impact of Pectin Supplementation on Intestinal Barrier Function in Healthy Young Adults and Healthy Elderly. (2019). https://pubmed.ncbi.nlm.nih.gov/31324040/ DOI: 10.3390/nu11071554","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"13c3aae7-702f-5bc9-9fca-a57d141882ce","stable_key":"import-d17caac5-7018-5ca8-9e96-95afeb384bc4","title":"Pectin: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ff07001bc37d008a1e23fbba37146d0b0d33cc8c0bf42a75f1e1a7ef0aaeb489","revision_id":"76f1a2c5-02d0-511b-bde5-33079d7af6a0","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}