{"id":"ffb9198d-997b-5e1c-bf54-24ecab4f47d3","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-oxidation-remodel","predicate":"supports_remodeling_of","statement":"Remodeling of the tested mature amyloid preparations depended on EGCG autooxidation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"704de177-1698-5efe-9a61-ed8aed82f857","mechanism_event_label":"The oxidation state helped determine aggregate remodeling.","subject":{"id":"8e66ddcc-1636-5054-b366-703d8ea568ba","slug":"oxidized-egcg-pool","display_name":"Oxidized EGCG reaction products, unresolved mixture","entity_type_key":"chemical_species"},"object":{"id":"f2b6bdc9-76e1-5cd8-b893-e18d774403a5","slug":"amyloid-beta-fibrils","display_name":"Amyloid-beta fibrils, sequence specified by study","entity_type_key":"protein_state"},"evidence_count":1,"mechanism_event":{"id":"704de177-1698-5efe-9a61-ed8aed82f857","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-oxidation-remodel-event","event_type":"observed_relationship","label":"The oxidation state helped determine aggregate remodeling.","description":"Remodeling of the tested mature amyloid preparations depended on EGCG autooxidation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8e66ddcc-1636-5054-b366-703d8ea568ba","slug":"oxidized-egcg-pool","display_name":"Oxidized EGCG reaction products, unresolved mixture","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f2b6bdc9-76e1-5cd8-b893-e18d774403a5","slug":"amyloid-beta-fibrils","display_name":"Amyloid-beta fibrils, sequence specified by study","entity_type_key":"protein_state"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Amyloid-beta 1–40 and IAPP/Sup35 fragment preparations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Fragment and in-vitro oxidation contexts limit generalization.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The oxidation state helped determine aggregate remodeling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Toward the molecular mechanism(s) by which EGCG treatment remodels mature amyloid fibrils. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23611538/ · DOI 10.1021/ja3115696","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a530ee16-2c05-50dd-87e7-3c8a8caf079e","evidence_kind":"source_excerpt","locator":"Lines 380-386","start_line":380,"end_line":386,"excerpt":"## egcg-oxidation-remodel\nThe oxidation state helped determine aggregate remodeling.\nRemodeling of the tested mature amyloid preparations depended on EGCG autooxidation.\nModel: Amyloid-beta 1–40 and IAPP/Sup35 fragment preparations.\nLimitations: Fragment and in-vitro oxidation contexts limit generalization.\nEvidence access: primary abstract.\nToward the molecular mechanism(s) by which EGCG treatment remodels mature amyloid fibrils. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23611538/ · DOI 10.1021/ja3115696","model_system":"Amyloid-beta 1–40 and IAPP/Sup35 fragment preparations.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}