{"id":"ff8993cb-a9f2-5151-b7ae-e4c220890fbb","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-controlled-feeding-pressure","predicate":"supplementation_reduces","statement":"Potassium supplementation reduced 24-hour pressure by approximately 3.9/1.6 mmHg under controlled feeding.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"1a6a5a1f-28aa-5dac-bc38-c211796410d8","mechanism_event_label":"The blood-pressure effect was measured directly in this trial.","subject":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"object":{"id":"9eda1162-1823-5c43-8e7d-4f2e4858c353","slug":"blood-pressure","display_name":"Arterial blood pressure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1a6a5a1f-28aa-5dac-bc38-c211796410d8","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-controlled-feeding-pressure-event","event_type":"observed_intervention","label":"The blood-pressure effect was measured directly in this trial.","description":"Potassium supplementation reduced 24-hour pressure by approximately 3.9/1.6 mmHg under controlled feeding.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e4aaa90-5b94-5d69-ba79-d760da4e0268","slug":"sodium","display_name":"Sodium","entity_type_key":"nutrient_element"},"role":"controlled_diet_context","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4b7ee17d-c11a-5a38-acf1-468d751ce3dd","slug":"arterial-stiffness","display_name":"Arterial stiffness","entity_type_key":"cellular_process"},"role":"bounded_null_endpoint","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9eda1162-1823-5c43-8e7d-4f2e4858c353","slug":"blood-pressure","display_name":"Arterial blood pressure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Four-week crossover; 36 completers.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Untreated elevated-pressure adults with relatively low baseline sodium/potassium intake; no detected pulse-wave-velocity benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The blood-pressure effect was measured directly in this trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k-gijsbers2015-bp] Effects of sodium and potassium supplementation on blood pressure and arterial stiffness: a fully controlled dietary intervention study (2015). https://pubmed.ncbi.nlm.nih.gov/25673113/ DOI: 10.1038/jhh.2015.3","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Systemic circulation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"40c0e3ee-fa95-52dc-a9ee-e8799dd61ca2","evidence_kind":"source_excerpt","locator":"Lines 1546-1555","start_line":1546,"end_line":1555,"excerpt":"### k-controlled-feeding-pressure\nPotassium supplementation reduced 24-hour pressure by approximately 3.9/1.6 mmHg under controlled feeding.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The blood-pressure effect was measured directly in this trial.\norganism: Homo sapiens\ntissue_or_cell_type: Systemic circulation\nexperimental_model: Four-week crossover; 36 completers.\nlimitations: Untreated elevated-pressure adults with relatively low baseline sodium/potassium intake; no detected pulse-wave-velocity benefit.\n[k-gijsbers2015-bp] Effects of sodium and potassium supplementation on blood pressure and arterial stiffness: a fully controlled dietary intervention study (2015). https://pubmed.ncbi.nlm.nih.gov/25673113/ DOI: 10.1038/jhh.2015.3","model_system":"Four-week crossover; 36 completers.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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