{"id":"ff6ac709-ca98-5b8c-af55-b08fac81c61c","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-apip-inflammatory-death","predicate":"limits_tested","statement":"Reduced APIP expression or added MTA increased Salmonella-induced cell death in the human-cell study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"eaae468c-a681-5fb6-9210-5556fa1c4580","mechanism_event_label":"A salvage pathway also intersected with inflammatory cell death.","subject":{"id":"d4e3b8c8-690d-58ba-8a00-99221988daf8","slug":"apip","display_name":"Human methylthioribulose-1-phosphate dehydratase / APIP","entity_type_key":"protein"},"object":{"id":"6ba6bc7b-f192-544b-98c9-a8962fb340ad","slug":"human-salmonella-caspase1-cell-death","display_name":"Salmonella-induced caspase-1 cell death in human-cell assays","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"eaae468c-a681-5fb6-9210-5556fa1c4580","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-apip-inflammatory-death-event","event_type":"observed_relationship","label":"A salvage pathway also intersected with inflammatory cell death.","description":"Reduced APIP expression or added MTA increased Salmonella-induced cell death in the human-cell study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d4e3b8c8-690d-58ba-8a00-99221988daf8","slug":"apip","display_name":"Human methylthioribulose-1-phosphate dehydratase / APIP","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6ba6bc7b-f192-544b-98c9-a8962fb340ad","slug":"human-salmonella-caspase1-cell-death","display_name":"Salmonella-induced caspase-1 cell death in human-cell assays","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"525860da-a986-5d19-97f0-a257a454b649","slug":"5-methylthioadenosine","display_name":"5′-Methylthioadenosine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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