{"id":"ff2d586d-e567-53ad-8f22-b70a78042491","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:folate-portal-formyl-to-methyl-conversion","predicate":"converted-to","statement":"After oral labeled 6S-5-formylTHF, portal folate was predominantly labeled 5-MTHF at 15 minutes; unchanged formylTHF was 4 ± 18%.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"6634ae86-2a11-5fdd-8ef0-831ad1c3e784","mechanism_event_label":"The gut readily processed the reduced folate in this comparison.","subject":{"id":"bab4af27-0401-545c-aa8f-e945920e614b","slug":"5-formyltetrahydrofolate","display_name":"5-Formyltetrahydrofolate","entity_type_key":"small_molecule"},"object":{"id":"23f48782-478e-5f62-874a-31273c075fe7","slug":"5-methyltetrahydrofolate","display_name":"5-Methyltetrahydrofolate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"6634ae86-2a11-5fdd-8ef0-831ad1c3e784","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:folate-portal-formyl-to-methyl-conversion-event","event_type":"observed_intervention","label":"The gut readily processed the reduced folate in this comparison.","description":"After oral labeled 6S-5-formylTHF, portal folate was predominantly labeled 5-MTHF at 15 minutes; unchanged formylTHF was 4 ± 18%.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bab4af27-0401-545c-aa8f-e945920e614b","slug":"5-formyltetrahydrofolate","display_name":"5-Formyltetrahydrofolate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"23f48782-478e-5f62-874a-31273c075fe7","slug":"5-methyltetrahydrofolate","display_name":"5-Methyltetrahydrofolate","entity_type_key":"small_molecule"},"role":"object","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Portal/peripheral isotope crossover in six TIPSS patients","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"500 nmol labeled 6S-5-formylTHF; four comparator participants","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not show superiority for clinical outcomes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"folate","display_name":"Folate (vitamin B9)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The gut readily processed the reduced folate in this comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[patanwala2014] Folic acid handling by the human gut: implications for food fortification and supplementation (2014). https://pubmed.ncbi.nlm.nih.gov/24944062/ DOI: 10.3945/ajcn.113.080507","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Hepatic portal blood","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d9a4598e-0474-51cf-b6f1-19bbc0a3a85c","evidence_kind":"source_excerpt","locator":"Lines 399-409","start_line":399,"end_line":409,"excerpt":"### folate-portal-formyl-to-methyl-conversion\nAfter oral labeled 6S-5-formylTHF, portal folate was predominantly labeled 5-MTHF at 15 minutes; unchanged formylTHF was 4 ± 18%.\nCondition category: normal\nnutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The gut readily processed the reduced folate in this comparison.\norganism: Homo sapiens\ntissue_or_cell_type: Hepatic portal blood\nexperimental_model: Portal/peripheral isotope crossover in six TIPSS patients\nlimitations: Does not show superiority for clinical outcomes.\nexposure: 500 nmol labeled 6S-5-formylTHF; four comparator participants\n[patanwala2014] Folic acid handling by the human gut: implications for food fortification and supplementation (2014). https://pubmed.ncbi.nlm.nih.gov/24944062/ DOI: 10.3945/ajcn.113.080507","model_system":"Portal/peripheral isotope crossover in six TIPSS patients","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [patanwala2014] Folic acid handling by the human gut: implications for food fortification and supplementation (2014). https://pubmed.ncbi.nlm.nih.gov/24944062/ DOI: 10.3945/ajcn.113.080507","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f4ce1a62-9582-5f7a-84f5-a23d0e1bfc68","stable_key":"import-ec174d5a-4903-5745-8646-df0e9d4265e8","title":"Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e564d43989ece1006c95cd0748e9af6fe369074599a2eebba0a99ebff864b0dd","revision_id":"76674a33-b2a1-5e41-b71b-44399038ff7c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}