{"id":"fefec15d-5ff7-5706-a3b4-22c8d78460d9","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-human-acetate-conversion","predicate":"microbially_converted_to","statement":"Colon-delivered isotope tracing in 12 healthy people estimated 24% conversion of acetate into butyrate, the largest measured SCFA interconversion.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e64486ba-b86e-5e35-b850-25c62494daf9","mechanism_event_label":"Cross-feeding was detectable in humans as well as cultures.","subject":{"id":"e366e758-1fb0-5573-aed1-34f6df874ac7","slug":"acetate","display_name":"Acetate","entity_type_key":"small_molecule"},"object":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"e64486ba-b86e-5e35-b850-25c62494daf9","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-human-acetate-conversion-event","event_type":"observed_relationship","label":"Cross-feeding was detectable in humans as well as cultures.","description":"Colon-delivered isotope tracing in 12 healthy people estimated 24% conversion of acetate into butyrate, the largest measured SCFA interconversion.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e366e758-1fb0-5573-aed1-34f6df874ac7","slug":"acetate","display_name":"Acetate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human stable-isotope colon-delivery study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A study-specific tracer estimate, not a recommended acetate dose or a universal conversion fraction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Cross-feeding was detectable in humans as well as cultures.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Systemic availability and metabolism of colonic-derived short-chain fatty acids in healthy subjects: a stable isotope study. · 2017 · https://pubmed.ncbi.nlm.nih.gov/27510655/ · DOI 10.1113/JP272613","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fc7342c6-fe9c-51ee-bbf4-afe177b75b34","evidence_kind":"source_excerpt","locator":"Lines 94-100","start_line":94,"end_line":100,"excerpt":"## butyrate-human-acetate-conversion\nCross-feeding was detectable in humans as well as cultures.\nColon-delivered isotope tracing in 12 healthy people estimated 24% conversion of acetate into butyrate, the largest measured SCFA interconversion.\nModel: Human stable-isotope colon-delivery study.\nLimitations: A study-specific tracer estimate, not a recommended acetate dose or a universal conversion fraction.\nEvidence access: Primary abstract\nSystemic availability and metabolism of colonic-derived short-chain fatty acids in healthy subjects: a stable isotope study. · 2017 · https://pubmed.ncbi.nlm.nih.gov/27510655/ · DOI 10.1113/JP272613","model_system":"Human stable-isotope colon-delivery study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"33205bb8-dcbe-5d2c-afca-86075d7748d1","stable_key":"import-104835a3-b891-5dc4-a6bb-42ab7c6f96c4","title":"Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"a1253eb4426fc45d7b7c113028aa4ba2e9f89a9653272f3795437fc222bad558","revision_id":"c2320e65-a252-57a9-8838-7abf3d23400e","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}