{"id":"feb422ef-4122-5dbc-86f4-4cd056e1776b","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-human-fgf-heat","predicate":"associated_with_lower","statement":"FGF21 induction was associated with decreased thermogenesis and adiponectin.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e5fe7a4c-a55d-53df-8bcd-5e73be497e92","mechanism_event_label":"Late starvation signaling accompanied energy conservation.","subject":{"id":"5ab67f11-d51b-5ec9-8eaf-e40815f1fc1a","slug":"fgf21","display_name":"Human fibroblast growth factor 21 / FGF21","entity_type_key":"protein"},"object":{"id":"b34a18ce-f025-5502-94ac-7f6f3bb93769","slug":"thermogenesis","display_name":"Thermogenesis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e5fe7a4c-a55d-53df-8bcd-5e73be497e92","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-human-fgf-heat-event","event_type":"observed_relationship","label":"Late starvation signaling accompanied energy conservation.","description":"FGF21 induction was associated with decreased thermogenesis and adiponectin.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5ab67f11-d51b-5ec9-8eaf-e40815f1fc1a","slug":"fgf21","display_name":"Human fibroblast growth factor 21 / FGF21","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b34a18ce-f025-5502-94ac-7f6f3bb93769","slug":"thermogenesis","display_name":"Thermogenesis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract; protocol checked in PMC4665770","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Eleven volunteers; ten-day fast with daily multivitamin, 20 mEq potassium chloride and 200 mg allopurinol.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Association does not prove FGF21 caused either decrease.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"Late starvation signaling accompanied energy conservation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"FGF21 and the late adaptive response to starvation in humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26529252/ · DOI 10.1172/JCI83349","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f219dadc-731f-5383-94b6-52874d5b3082","evidence_kind":"source_excerpt","locator":"Lines 288-294","start_line":288,"end_line":294,"excerpt":"## fast-human-fgf-heat\nLate starvation signaling accompanied energy conservation.\nFGF21 induction was associated with decreased thermogenesis and adiponectin.\nModel: Eleven volunteers; ten-day fast with daily multivitamin, 20 mEq potassium chloride and 200 mg allopurinol.\nLimitations: Association does not prove FGF21 caused either decrease.\nEvidence access: Primary abstract; protocol checked in PMC4665770\nFGF21 and the late adaptive response to starvation in humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26529252/ · DOI 10.1172/JCI83349","model_system":"Eleven volunteers; ten-day fast with daily multivitamin, 20 mEq potassium chloride and 200 mg allopurinol.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}