{"id":"feb26962-7de4-563c-a26a-7d6b706c4ae8","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-chick-cartilage","predicate":"impairs","statement":"Silicon-deprived chicks showed abnormal epiphyseal cartilage and lower tibial hexosamine/collagen measures.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8e418024-5c2a-5abb-9fe4-ca96507b414d","mechanism_event_label":"Growing-animal cartilage was sensitive to the experimental diet.","subject":{"id":"9a2dfc36-c61f-5d10-9105-aa189af7db53","slug":"chick-low-silicon-diet","display_name":"Low-silicon experimental chick diet","entity_type_key":"cellular_process"},"object":{"id":"37891882-e966-507c-989f-8d60d3baf888","slug":"chick-endochondral-bone-growth","display_name":"Endochondral bone growth in chicks","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8e418024-5c2a-5abb-9fe4-ca96507b414d","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-chick-cartilage-event","event_type":"observed_relationship","label":"Growing-animal cartilage was sensitive to the experimental diet.","description":"Silicon-deprived chicks showed abnormal epiphyseal cartilage and lower tibial hexosamine/collagen measures.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9a2dfc36-c61f-5d10-9105-aa189af7db53","slug":"chick-low-silicon-diet","display_name":"Low-silicon experimental chick diet","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"37891882-e966-507c-989f-8d60d3baf888","slug":"chick-endochondral-bone-growth","display_name":"Endochondral bone growth in chicks","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Four-week cockerels on casein-based diets.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Developmental animal model, not a human nutritional threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Growing-animal cartilage was sensitive to the experimental diet.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Biochemical and morphological changes associated with long bone abnormalities in silicon deficiency. · 1980 · https://pubmed.ncbi.nlm.nih.gov/7373430/ · DOI 10.1093/jn/110.5.1046","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"4e2327fe-df23-53c9-910b-876fca366fae","evidence_kind":"source_excerpt","locator":"Lines 368-374","start_line":368,"end_line":374,"excerpt":"## silica-chick-cartilage\nGrowing-animal cartilage was sensitive to the experimental diet.\nSilicon-deprived chicks showed abnormal epiphyseal cartilage and lower tibial hexosamine/collagen measures.\nModel: Four-week cockerels on casein-based diets.\nLimitations: Developmental animal model, not a human nutritional threshold.\nEvidence access: Primary abstract\nBiochemical and morphological changes associated with long bone abnormalities in silicon deficiency. · 1980 · https://pubmed.ncbi.nlm.nih.gov/7373430/ · DOI 10.1093/jn/110.5.1046","model_system":"Four-week cockerels on casein-based diets.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc4b461e-dd46-57ab-8213-8aeb7ff9e8d0","stable_key":"import-3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd","title":"Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"e05d81962a1ca6cbfc68fce4fd3dbcdea67c8e61332c19f4fec5d0c3ab8bf1b9","revision_id":"6433ed49-a331-571b-a611-21e56c3ce4bc","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}