{"id":"fe673dcb-10b7-561b-a533-f9bd657c597d","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-quinone-mobility","predicate":"under_hypoxic_pathway_reduces","statement":"The sodium-linked membrane change reduced free ubiquinone mobility between complexes II and III, while transport within supercomplexes was spared.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5565515c-dd78-5a32-83e3-6447c8c85584","mechanism_event_label":"The effect depended on how the respiratory machinery was organized.","subject":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"object":{"id":"793168ef-e8d8-5bca-8fce-209b8d804d01","slug":"free-ubiquinone-mobility","display_name":"Mobility of free ubiquinone between respiratory complexes II and III","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5565515c-dd78-5a32-83e3-6447c8c85584","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-quinone-mobility-event","event_type":"biochemical_relationship","label":"The effect depended on how the respiratory machinery was organized.","description":"The sodium-linked membrane change reduced free ubiquinone mobility between complexes II and III, while transport within supercomplexes was spared.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ae9544c3-df78-54f8-80e7-5b643e5ba1cf","slug":"ubiquinone","display_name":"Ubiquinone","entity_type_key":"small_molecule"},"role":"electron_carrier","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"793168ef-e8d8-5bca-8fce-209b8d804d01","slug":"free-ubiquinone-mobility","display_name":"Mobility of free ubiquinone between respiratory complexes II and III","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/sodium-research/32728214.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"2780431aa362c99c816f986e923fd65ed0c0324e8c8674af8ff2a2f9367762c1\", \"start_char\": 0, \"end_char\": 1533, \"text_sha256\": \"2780431aa362c99c816f986e923fd65ed0c0324e8c8674af8ff2a2f9367762c1\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Acute-hypoxia cellular and mitochondrial experiments with ion imaging and respiratory/membrane assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Acute hypoxia and inhibition of mitochondrial sodium/calcium exchange","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Mechanistic research under hypoxia, including multiple preparations. Do not infer that dietary salt drives this chain, that every tissue responds identically, or that ROS here proves disease.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sodium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sodium","display_name":"Sodium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human and mouse cells; additional rat vascular experiments in the paper","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The effect depended on how the respiratory machinery was organized.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[sodium-p32728214] Na+ controls hypoxic signalling by the mitochondrial respiratory chain. (2020). https://pubmed.ncbi.nlm.nih.gov/32728214/ DOI: 10.1038/s41586-020-2551-y","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Mitochondrial matrix and inner membrane","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"55b66f95-d81a-5468-b089-5d729d722601","evidence_kind":"source_excerpt","locator":"Lines 798-809","start_line":798,"end_line":809,"excerpt":"### sodium-quinone-mobility\nThe sodium-linked membrane change reduced free ubiquinone mobility between complexes II and III, while transport within supercomplexes was spared.\nCondition category: normal\nnutrient_topic: Sodium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The effect depended on how the respiratory machinery was organized.\norganism: Human and mouse cells; additional rat vascular experiments in the paper\ntissue_or_cell_type: Mitochondrial matrix and inner membrane\nexperimental_model: Acute-hypoxia cellular and mitochondrial experiments with ion imaging and respiratory/membrane assays\nlimitations: Mechanistic research under hypoxia, including multiple preparations. Do not infer that dietary salt drives this chain, that every tissue responds identically, or that ROS here proves disease.\nexposure: Acute hypoxia and inhibition of mitochondrial sodium/calcium exchange\nevidence_span: {\"source_cache\": \"artifacts/sodium-research/32728214.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"2780431aa362c99c816f986e923fd65ed0c0324e8c8674af8ff2a2f9367762c1\", \"start_char\": 0, \"end_char\": 1533, \"text_sha256\": \"2780431aa362c99c816f986e923fd65ed0c0324e8c8674af8ff2a2f9367762c1\"}\n[sodium-p32728214] Na+ controls hypoxic signalling by the mitochondrial respiratory chain. (2020). https://pubmed.ncbi.nlm.nih.gov/32728214/ DOI: 10.1038/s41586-020-2551-y","model_system":"Acute-hypoxia cellular and mitochondrial experiments with ion imaging and respiratory/membrane assays","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [sodium-p32728214] Na+ controls hypoxic signalling by the mitochondrial respiratory chain. (2020). https://pubmed.ncbi.nlm.nih.gov/32728214/ DOI: 10.1038/s41586-020-2551-y","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c260cd7b-beb0-5113-a198-69ec8fd4492c","stable_key":"import-195e8b84-ca5a-591a-a045-c55c53c8a01c","title":"Sodium: gradients, nutrient transport, fluid regulation and loss states (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"684f65cf0661c18395831ade4b02bb24d5e66c568f0d00a3471600eaf5d4d1c6","revision_id":"39866f04-3052-5f59-bd95-6806c5490875","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}