{"id":"fe37cdf0-1f49-5977-a965-ba7420e00d5a","stable_key":"c8c7aa13-14c6-5f5c-9afc-9217d0f2f736:hfcs-component-dnl","predicate":"increases","statement":"Fructose beverages increased basal hepatic fractional fatty-acid synthesis/secretion versus control after seven weeks.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"0fcdfcf1-ed04-53d5-96ec-180ceebf0837","mechanism_event_label":"Fructose beverages increased basal hepatic fractional fatty-acid synthesis/secretion versus control after seven weeks.","subject":{"id":"3c379840-5688-5b5d-84c0-5950b4fd8f17","slug":"fructose","display_name":"Fructose","entity_type_key":"small_molecule"},"object":{"id":"446e00c2-fffc-5c35-b806-146e1e763260","slug":"human-hepatic-fatty-acid-synthesis","display_name":"Human basal hepatic fractional fatty-acid synthesis/secretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0fcdfcf1-ed04-53d5-96ec-180ceebf0837","stable_key":"c8c7aa13-14c6-5f5c-9afc-9217d0f2f736:hfcs-component-dnl-event","event_type":"observed_relationship","label":"Fructose beverages increased basal hepatic fractional fatty-acid synthesis/secretion versus control after seven weeks.","description":"Fructose beverages increased basal hepatic fractional fatty-acid synthesis/secretion versus control after seven weeks.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3c379840-5688-5b5d-84c0-5950b4fd8f17","slug":"fructose","display_name":"Fructose","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"446e00c2-fffc-5c35-b806-146e1e763260","slug":"human-hepatic-fatty-acid-synthesis","display_name":"Human basal hepatic fractional fatty-acid synthesis/secretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Fructose, sucrose or glucose 80 g/day versus sweetened-beverage abstinence","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"7 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract/metadata; unrecovered methods explicitly retained.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"94 healthy men completing randomized beverage intervention","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_scope","value_text":"Component sugars and sucrose","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Total reported energy intake was similar across groups; this was not a metabolic-ward clamp. Fractional fatty-acid synthesis is distinct from total liver fat and VLDL-TG output. No HFCS arm.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"HFCS chapter: actual formulation studies, component biochemistry and interventions are explicitly distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"high-fructose-corn-syrup","display_name":"High-Fructose Corn Syrup / HFCS","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"94 healthy men completing randomized beverage intervention","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Fructose beverages increased basal hepatic fractional fatty-acid synthesis/secretion versus control after seven weeks.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial. (2021). https://pubmed.ncbi.nlm.nih.gov/33684506/ DOI: 10.1016/j.jhep.2021.02.027","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral beverages in addition to usual diet","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Stable-isotope hepatic lipid synthesis","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"295f976b-31af-5fa6-bc61-602446129f9c","evidence_kind":"source_excerpt","locator":"Lines 389-399","start_line":389,"end_line":399,"excerpt":"## hfcs-component-dnl\nFructose beverages increased basal hepatic fractional fatty-acid synthesis/secretion versus control after seven weeks.\nModel/species: 94 healthy men completing randomized beverage intervention\nTissue: Stable-isotope hepatic lipid synthesis\nExposure: Fructose, sucrose or glucose 80 g/day versus sweetened-beverage abstinence\nRoute: Oral beverages in addition to usual diet\nDuration: 7 weeks\nExposure scope: Component sugars and sucrose\nLimits: Total reported energy intake was similar across groups; this was not a metabolic-ward clamp. Fractional fatty-acid synthesis is distinct from total liver fat and VLDL-TG output. No HFCS arm.\nReference: Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial. (2021). https://pubmed.ncbi.nlm.nih.gov/33684506/ DOI: 10.1016/j.jhep.2021.02.027\nAccess: Primary abstract/metadata; unrecovered methods explicitly retained.","model_system":"94 healthy men completing randomized beverage intervention","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; provenance retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e863ddf6-7c1e-5a70-8335-7f3ac3eeee92","stable_key":"import-c8c7aa13-14c6-5f5c-9afc-9217d0f2f736","title":"High-Fructose Corn Syrup: mechanism of action and metabolic impact (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twenty primary studies and official FDA composition information, with one reused canonical glucose-transport claim. Study-specific citations, negative findings and limitations retained. Not publisher full text.","file_path":"","sha256":"f4721923a83b368d549ba110a4f8c8738026210b32f6d29f3bd3200aa420f3b3","revision_id":"45827d73-cb6d-5aff-969b-af364b74b168","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}