{"id":"fe02b087-b271-585c-82c3-3ca583caa0b8","stable_key":"cfa4bd86-d88d-555a-975c-68877bf00e0f:lutein-deprivation-pigment","predicate":"depletes","statement":"Lifelong xanthophyll-free animals had no detectable macular pigment.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"575d6857-634c-50a2-b3f6-924983e1edfc","mechanism_event_label":"The pigment pool disappeared under extreme dietary deprivation.","subject":{"id":"acf931e4-ebb8-5915-be60-4c02da2158a3","slug":"rhesus-xanthophyll-deprivation","display_name":"Lifelong xanthophyll-free diet in rhesus monkeys","entity_type_key":"chemical_species"},"object":{"id":"21754159-d019-5bb5-9377-f8b91a596e2f","slug":"rhesus-macular-pigment","display_name":"Rhesus macular pigment content","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"575d6857-634c-50a2-b3f6-924983e1edfc","stable_key":"cfa4bd86-d88d-555a-975c-68877bf00e0f:lutein-deprivation-pigment-event","event_type":"biochemical_relationship","label":"The pigment pool disappeared under extreme dietary deprivation.","description":"Lifelong xanthophyll-free animals had no detectable macular pigment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"acf931e4-ebb8-5915-be60-4c02da2158a3","slug":"rhesus-xanthophyll-deprivation","display_name":"Lifelong xanthophyll-free diet in rhesus monkeys","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"21754159-d019-5bb5-9377-f8b91a596e2f","slug":"rhesus-macular-pigment","display_name":"Rhesus macular pigment content","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lutein-research/21245404.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"74fa1a576a92084789e1a2d4afcd7c657e9ef2acaf9b0a6eaca46d543447ee2b\", \"start_char\": 0, \"end_char\": 1712, \"text_sha256\": \"74fa1a576a92084789e1a2d4afcd7c657e9ef2acaf9b0a6eaca46d543447ee2b\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Dietary deprivation/repletion and controlled laser challenge","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Eight lifelong xanthophyll-deprived animals, n-3 intake strata; 22–28 weeks L or Z; 476-nm exposures","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Extreme animal depletion and laser injury are not a defined human deficiency syndrome or ordinary screen exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lutein research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rhesus macaque","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The pigment pool disappeared under extreme dietary deprivation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lutein-p21245404] Nutritional manipulation of primate retinas, V: effects of lutein, zeaxanthin, and n-3 fatty acids on retinal sensitivity to blue-light-induced damage. (2011). https://pubmed.ncbi.nlm.nih.gov/21245404/ DOI: 10.1167/iovs.10-5898","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Foveal and parafoveal retina","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"efe82997-c5ea-570f-ae53-dd80f64e1218","evidence_kind":"source_excerpt","locator":"Lines 424-435","start_line":424,"end_line":435,"excerpt":"### lutein-deprivation-pigment\nLifelong xanthophyll-free animals had no detectable macular pigment.\nCondition category: nutrient_deficiency\nnutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The pigment pool disappeared under extreme dietary deprivation.\norganism: Rhesus macaque\ntissue_or_cell_type: Foveal and parafoveal retina\nexperimental_model: Dietary deprivation/repletion and controlled laser challenge\nlimitations: Extreme animal depletion and laser injury are not a defined human deficiency syndrome or ordinary screen exposure.\nexposure: Eight lifelong xanthophyll-deprived animals, n-3 intake strata; 22–28 weeks L or Z; 476-nm exposures\nevidence_span: {\"source_cache\": \"artifacts/lutein-research/21245404.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"74fa1a576a92084789e1a2d4afcd7c657e9ef2acaf9b0a6eaca46d543447ee2b\", \"start_char\": 0, \"end_char\": 1712, \"text_sha256\": \"74fa1a576a92084789e1a2d4afcd7c657e9ef2acaf9b0a6eaca46d543447ee2b\"}\n[lutein-p21245404] Nutritional manipulation of primate retinas, V: effects of lutein, zeaxanthin, and n-3 fatty acids on retinal sensitivity to blue-light-induced damage. (2011). https://pubmed.ncbi.nlm.nih.gov/21245404/ DOI: 10.1167/iovs.10-5898","model_system":"Dietary deprivation/repletion and controlled laser challenge","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [lutein-p21245404] Nutritional manipulation of primate retinas, V: effects of lutein, zeaxanthin, and n-3 fatty acids on retinal sensitivity to blue-light-induced damage. (2011). https://pubmed.ncbi.nlm.nih.gov/21245404/ DOI: 10.1167/iovs.10-5898","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"beef4241-6ebd-5b36-864c-6ef3ed7e61b8","stable_key":"import-cfa4bd86-d88d-555a-975c-68877bf00e0f","title":"Lutein: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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