{"id":"fddfba15-4d8f-5cd1-b3cd-4b60d3e0580b","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-tau-phosphorylation","predicate":"reduces_phosphorylation_of","statement":"Lithium reduced tau phosphorylation through reversible GSK3 inhibition in human NT2N neurons.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"c38fbeba-9ca3-5610-aa40-567c7ecf5693","mechanism_event_label":"A signaling enzyme changes chemical marks on a structural protein.","subject":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"object":{"id":"e6e12feb-ecfe-5217-8cfd-5184a502cceb","slug":"mapt","display_name":"Human microtubule-associated protein tau / MAPT","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"c38fbeba-9ca3-5610-aa40-567c7ecf5693","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-tau-phosphorylation-event","event_type":"observed_relationship","label":"A signaling enzyme changes chemical marks on a structural protein.","description":"Lithium reduced tau phosphorylation through reversible GSK3 inhibition in human NT2N neurons.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e6e12feb-ecfe-5217-8cfd-5184a502cceb","slug":"mapt","display_name":"Human microtubule-associated protein tau / MAPT","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9fe71ad0-5696-5db1-b0a6-082cdb115a28","slug":"gsk3b","display_name":"Human glycogen synthase kinase 3 beta / GSK3B","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cultured human NT2N neurons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not demonstrate dementia prevention in people.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"A signaling enzyme changes chemical marks on a structural protein.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3. · 1997 · https://pubmed.ncbi.nlm.nih.gov/9312151/ · DOI 10.1074/jbc.272.40.25326","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"799de80a-c4c8-5eba-9254-b1a3292f87e7","evidence_kind":"source_excerpt","locator":"Lines 176-182","start_line":176,"end_line":182,"excerpt":"## lithium-tau-phosphorylation\nA signaling enzyme changes chemical marks on a structural protein.\nLithium reduced tau phosphorylation through reversible GSK3 inhibition in human NT2N neurons.\nModel: Cultured human NT2N neurons.\nLimitations: Does not demonstrate dementia prevention in people.\nEvidence access: Primary abstract\nLithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3. · 1997 · https://pubmed.ncbi.nlm.nih.gov/9312151/ · DOI 10.1074/jbc.272.40.25326","model_system":"Cultured human NT2N neurons.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b2dd2f3c-5c4c-5a12-9a0d-91b521ffcf98","stable_key":"import-b7798a90-72a3-5454-a321-c4be88bf0cc4","title":"Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"dc67e965ba78458cf2d88d000d687641d9104354115ab16529a3a64941bd777d","revision_id":"4af127bf-9ccc-516b-9481-fafd453c2c35","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}