{"id":"fdc0399c-3e81-51a5-8309-6551dcf86cfb","stable_key":"788beb7b-7928-5f89-83d4-5556abf3702c:fulvic-acid-airway-iron-rescue","predicate":"reduces_cotreatment_response","statement":"Iron co-exposure reduced fulvic-associated IL-6/IL-8 release in the tested cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4b853c87-5ccf-50b0-9e38-a3496801785a","mechanism_event_label":"Adding iron altered the inflammatory response in this experiment.","subject":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"object":{"id":"b2cee679-0554-5a97-a7f9-42746cde031e","slug":"human-airway-fa-cytokines","display_name":"Cytokine release after reference fulvic exposure in airway cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4b853c87-5ccf-50b0-9e38-a3496801785a","stable_key":"788beb7b-7928-5f89-83d4-5556abf3702c:fulvic-acid-airway-iron-rescue-event","event_type":"observed_relationship","label":"Adding iron altered the inflammatory response in this experiment.","description":"Iron co-exposure reduced fulvic-associated IL-6/IL-8 release in the tested cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b2cee679-0554-5a97-a7f9-42746cde031e","slug":"human-airway-fa-cytokines","display_name":"Cytokine release after reference fulvic exposure in airway cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0aa6c0fc-8374-56e0-b172-6c40b6366d21","slug":"fulvic-acid","display_name":"Fulvic acid (heterogeneous humic fraction)","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"b7371865-cb83-5b2e-a5ad-45edfeea09c5","slug":"suwannee-river-fulvic-acid","display_name":"Suwannee River fulvic acid reference material","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"bf6dbaf0-1379-5ae1-9d27-aa46fab2e49a","slug":"nordic-fulvic-acid","display_name":"Nordic fulvic acid reference material","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"ef8f8807-395d-5dc6-9693-70e90f41b268","slug":"il6","display_name":"IL6","entity_type_key":"cytokine"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""},{"entity":{"id":"5dd031e8-9ede-5db7-a4e1-961de31f0b49","slug":"cxcl8","display_name":"Human interleukin-8 / CXCL8","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":6,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human respiratory epithelial-cell exposure to Suwannee River/Nordic reference fulvic fractions; comparison with smoke water-soluble fractions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Abstract access; exposure concentration and duration require full-method verification. Increased iron import is consistent with compensatory iron stress, not direct quantification of every intracellular available-iron pool. These are airway-cell exposures, not an oral trial. This is not a recommendation to supplement iron or proof of systemic iron deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fulvic acid collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fulvic-acid","display_name":"Fulvic acid (heterogeneous humic fraction)","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Adding iron altered the inflammatory response in this experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"A Fulvic Acid-like Substance Participates in the Pro-inflammatory Effects of Cigarette Smoke and Wood Smoke Particles. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32191033/ · DOI 10.1021/acs.chemrestox.0c00036","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"947ff2e6-2013-5cfc-ae4a-e45459035c58","evidence_kind":"source_excerpt","locator":"Lines 228-234","start_line":228,"end_line":234,"excerpt":"## fulvic-acid-airway-iron-rescue\nAdding iron altered the inflammatory response in this experiment.\nIron co-exposure reduced fulvic-associated IL-6/IL-8 release in the tested cells.\nModel: Human respiratory epithelial-cell exposure to Suwannee River/Nordic reference fulvic fractions; comparison with smoke water-soluble fractions.\nLimitations: Abstract access; exposure concentration and duration require full-method verification. Increased iron import is consistent with compensatory iron stress, not direct quantification of every intracellular available-iron pool. These are airway-cell exposures, not an oral trial. This is not a recommendation to supplement iron or proof of systemic iron deficiency.\nEvidence access: Primary abstract\nA Fulvic Acid-like Substance Participates in the Pro-inflammatory Effects of Cigarette Smoke and Wood Smoke Particles. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32191033/ · DOI 10.1021/acs.chemrestox.0c00036","model_system":"Human respiratory epithelial-cell exposure to Suwannee River/Nordic reference fulvic fractions; comparison with smoke water-soluble fractions.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b00a1818-46e4-52cc-8dfe-a647d5c08ed7","stable_key":"import-788beb7b-7928-5f89-83d4-5556abf3702c","title":"Fulvic acid: mixture identity, mineral chemistry, signaling and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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