{"id":"fd82f6e9-421e-5de7-b029-9eab1c857fca","stable_key":"d39c4b36-9a88-5f52-8e6b-93a248dc4bfc:hericenones-erinacines-deacylhericenone-activity","predicate":"more_strongly_increases","statement":"Deacylhericenone produced greater BDNF mRNA expression and hydrogen-peroxide protection than parent hericenone C in 1321N1 cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"c19b7ff1-d7a6-51c7-b960-af46ae2d4294","mechanism_event_label":"Deacylhericenone produced greater BDNF mRNA expression and hydrogen-peroxide protection than parent hericenone C in 1321N1 cells.","subject":{"id":"9dadb141-158f-5871-9118-4243be47da1c","slug":"deacylhericenone","display_name":"Deacylhericenone","entity_type_key":"small_molecule"},"object":{"id":"25abdb08-9191-5bde-b58a-6df452fd281c","slug":"human-astrocytoma-bdnf-and-oxidative-protection","display_name":"BDNF expression and oxidative-stress protection in human 1321N1 cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c19b7ff1-d7a6-51c7-b960-af46ae2d4294","stable_key":"d39c4b36-9a88-5f52-8e6b-93a248dc4bfc:hericenones-erinacines-deacylhericenone-activity-event","event_type":"observed_relationship","label":"Deacylhericenone produced greater BDNF mRNA expression and hydrogen-peroxide protection than parent hericenone C in 1321N1 cells.","description":"Deacylhericenone produced greater BDNF mRNA expression and hydrogen-peroxide protection than parent hericenone C in 1321N1 cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9dadb141-158f-5871-9118-4243be47da1c","slug":"deacylhericenone","display_name":"Deacylhericenone","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"25abdb08-9191-5bde-b58a-6df452fd281c","slug":"human-astrocytoma-bdnf-and-oxidative-protection","display_name":"BDNF expression and oxidative-stress protection in human 1321N1 cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"631eaf08-b37b-54d0-910c-7ab40cae5b96","slug":"hericenone-c","display_name":"Hericenone C","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"792bad91-27bf-55e8-aefc-9db5c3ceef7d","slug":"human-bdnf","display_name":"Human brain-derived neurotrophic factor / BDNF","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Deacylhericenone versus hericenone C","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Acute","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human 1321N1 astrocytoma cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The comparison does not establish human absorption, brain exposure, or clinical neuroprotection.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Hericenones & Erinacines chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"hericenones-erinacines","display_name":"Hericenones and erinacines","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human 1321N1 astrocytoma cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Deacylhericenone produced greater BDNF mRNA expression and hydrogen-peroxide protection than parent hericenone C in 1321N1 cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Deacylated Derivative of Hericenone C Treated by Lipase Shows Enhanced Neuroprotective Properties Compared to Its Parent Compound. (2023). https://pubmed.ncbi.nlm.nih.gov/37299024/ DOI: 10.3390/molecules28114549","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"BDNF mRNA and cell protection","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0c9009d9-405e-5868-8cfa-24eee18b658d","evidence_kind":"source_excerpt","locator":"Lines 77-86","start_line":77,"end_line":86,"excerpt":"## hericenones-erinacines-deacylhericenone-activity\nDeacylhericenone produced greater BDNF mRNA expression and hydrogen-peroxide protection than parent hericenone C in 1321N1 cells.\nModel/species: Human 1321N1 astrocytoma cells\nTissue/system: BDNF mRNA and cell protection\nExposure: Deacylhericenone versus hericenone C\nRoute: In vitro\nDuration: Acute\nLimits: The comparison does not establish human absorption, brain exposure, or clinical neuroprotection.\nPrimary reference: Deacylated Derivative of Hericenone C Treated by Lipase Shows Enhanced Neuroprotective Properties Compared to Its Parent Compound. (2023). https://pubmed.ncbi.nlm.nih.gov/37299024/ DOI: 10.3390/molecules28114549\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Human 1321N1 astrocytoma cells","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"aa7c09fd-ab4a-51ff-b463-d35547dc41ba","stable_key":"import-d39c4b36-9a88-5f52-8e6b-93a248dc4bfc","title":"Hericenones & Erinacines: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. 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