{"id":"fd5d6430-7108-5d38-be29-ddb3e3129d8d","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-thyroid-wnt-growth","predicate":"increases","statement":"At 5 mM LiCl, thyrocyte proliferation increased; dominant-negative TCF4 reduced this response by about half.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"911424c5-5321-5715-a857-9738b57ca31d","mechanism_event_label":"Blocking a downstream regulator weakened the growth response.","subject":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"object":{"id":"efb7e431-cb10-56ba-a179-b3ca378b166c","slug":"human-thyrocyte-proliferation","display_name":"Human cultured-thyrocyte proliferation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"911424c5-5321-5715-a857-9738b57ca31d","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-thyroid-wnt-growth-event","event_type":"observed_relationship","label":"Blocking a downstream regulator weakened the growth response.","description":"At 5 mM LiCl, thyrocyte proliferation increased; dominant-negative TCF4 reduced this response by about half.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"efb7e431-cb10-56ba-a179-b3ca378b166c","slug":"human-thyrocyte-proliferation","display_name":"Human cultured-thyrocyte proliferation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"79f18db5-3833-52d2-8136-94e295f4ef8a","slug":"ctnnb1","display_name":"Human beta-catenin / CTNNB1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"b01363cb-357a-51f7-8ba9-e5ca23690382","slug":"lithium-chloride","display_name":"Lithium chloride","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human cultured thyrocytes; TCF4 versus CREB pathway perturbation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"High cell-culture exposure; not a quantified human goiter or cancer risk.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Blocking a downstream regulator weakened the growth response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Lithium stimulates proliferation in cultured thyrocytes by activating Wnt/beta-catenin signalling. · 2005 · https://pubmed.ncbi.nlm.nih.gov/16322400/ · DOI 10.1530/eje.1.02038","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2d6426c5-89a8-51ae-8cf0-e92fb53b51d1","evidence_kind":"source_excerpt","locator":"Lines 416-422","start_line":416,"end_line":422,"excerpt":"## lithium-thyroid-wnt-growth\nBlocking a downstream regulator weakened the growth response.\nAt 5 mM LiCl, thyrocyte proliferation increased; dominant-negative TCF4 reduced this response by about half.\nModel: Human cultured thyrocytes; TCF4 versus CREB pathway perturbation.\nLimitations: High cell-culture exposure; not a quantified human goiter or cancer risk.\nEvidence access: Primary abstract\nLithium stimulates proliferation in cultured thyrocytes by activating Wnt/beta-catenin signalling. · 2005 · https://pubmed.ncbi.nlm.nih.gov/16322400/ · DOI 10.1530/eje.1.02038","model_system":"Human cultured thyrocytes; TCF4 versus CREB pathway perturbation.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b2dd2f3c-5c4c-5a12-9a0d-91b521ffcf98","stable_key":"import-b7798a90-72a3-5454-a321-c4be88bf0cc4","title":"Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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