{"id":"fd162db5-a69a-500a-b08a-75038d958d3a","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:lysine-renal-case-association","predicate":"oral_use_temporally_associated_with","statement":"A single case report associated oral lysine ingestion with Fanconi syndrome, severe tubulointerstitial nephritis, and subsequent chronic renal failure.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"10d93e8d-beab-5e66-9615-30bf86fae469","mechanism_event_label":"This is a safety signal from one patient, not an established frequency or proof of cause.","subject":{"id":"5fff6664-209e-5c35-b88e-ac15c1c5fbc0","slug":"l-lysine","display_name":"L-Lysine","entity_type_key":"small_molecule"},"object":{"id":"07f9d6d7-6009-50ab-95dd-41a2a5d2be0b","slug":"fanconi-tubulointerstitial-nephritis","display_name":"Fanconi syndrome with tubulointerstitial nephritis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"10d93e8d-beab-5e66-9615-30bf86fae469","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:lysine-renal-case-association-event","event_type":"observed_intervention","label":"This is a safety signal from one patient, not an established frequency or proof of cause.","description":"A single case report associated oral lysine ingestion with Fanconi syndrome, severe tubulointerstitial nephritis, and subsequent chronic renal failure.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5fff6664-209e-5c35-b88e-ac15c1c5fbc0","slug":"l-lysine","display_name":"L-Lysine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"07f9d6d7-6009-50ab-95dd-41a2a5d2be0b","slug":"fanconi-tubulointerstitial-nephritis","display_name":"Fanconi syndrome with tubulointerstitial nephritis","entity_type_key":"cellular_process"},"role":"object","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Single clinical case report","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No controlled comparison; susceptible individuals, coexposures, causality, and incidence cannot be resolved from this report.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This is a safety signal from one patient, not an established frequency or proof of cause.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lo1996] Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion (1996). https://pubmed.ncbi.nlm.nih.gov/8840955/ DOI: 10.1016/s0272-6386(96)90476-x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Renal tubules and interstitium","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"aeb31640-429e-53d5-aa47-2592c74adba0","evidence_kind":"source_excerpt","locator":"Lines 789-797","start_line":789,"end_line":797,"excerpt":"### lysine-renal-case-association\nA single case report associated oral lysine ingestion with Fanconi syndrome, severe tubulointerstitial nephritis, and subsequent chronic renal failure.\nPlain language: This is a safety signal from one patient, not an established frequency or proof of cause.\nCondition category: normal\norganism: Homo sapiens\ntissue_or_cell_type: Renal tubules and interstitium\nexperimental_model: Single clinical case report\nlimitations: No controlled comparison; susceptible individuals, coexposures, causality, and incidence cannot be resolved from this report.\n[lo1996] Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion (1996). https://pubmed.ncbi.nlm.nih.gov/8840955/ DOI: 10.1016/s0272-6386(96)90476-x","model_system":"Single clinical case report","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact quote from the accompanying curation document, not from publisher text. Original study references: [lo1996] Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion (1996). https://pubmed.ncbi.nlm.nih.gov/8840955/ DOI: 10.1016/s0272-6386(96)90476-x","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7633bde7-dcc9-5086-91c6-a45eb96857f3","stable_key":"import-c3df3634-4c3a-5099-a5d9-e4f6344c1084","title":"L-Lysine: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"93998d47c21525409ba82f1c82ededf2893dff15fbe61c7deffc175b0e298e97","revision_id":"3897e31f-6624-59e1-a053-8a81b7361632","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}