{"id":"fd04da38-bc35-55d8-a05f-f89b111dfee8","stable_key":"a9828b14-fbd7-57bf-9e01-0d52d1b42a1f:citrulline-citrin-aspartate","predicate":"mediates","statement":"Reconstituted citrin exchanged aspartate for glutamate plus a proton.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ecde010b-413c-5820-954a-fcbb90ee0afc","mechanism_event_label":"Moving aspartate between compartments helps connect nitrogen handling and redox metabolism.","subject":{"id":"5252ba8d-8e58-5fa5-abdb-7bc97ef85818","slug":"slc25a13","display_name":"Human citrin / SLC25A13","entity_type_key":"protein"},"object":{"id":"87e2aee0-43c6-5c6b-8dc7-3e4a85ec818e","slug":"mitochondrial-aspartate-glutamate-exchange","display_name":"Mitochondrial aspartate/glutamate exchange","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ecde010b-413c-5820-954a-fcbb90ee0afc","stable_key":"a9828b14-fbd7-57bf-9e01-0d52d1b42a1f:citrulline-citrin-aspartate-event","event_type":"biochemical_relationship","label":"Moving aspartate between compartments helps connect nitrogen handling and redox metabolism.","description":"Reconstituted citrin exchanged aspartate for glutamate plus a proton.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0a0923d3-72b7-5d6a-bf3a-5a7a3071a09b","slug":"l-aspartate","display_name":"L-Aspartate","entity_type_key":"small_molecule"},"role":"exchanged_substrate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"exchanged_substrate","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5252ba8d-8e58-5fa5-abdb-7bc97ef85818","slug":"slc25a13","display_name":"Human citrin / SLC25A13","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"87e2aee0-43c6-5c6b-8dc7-3e4a85ec818e","slug":"mitochondrial-aspartate-glutamate-exchange","display_name":"Mitochondrial aspartate/glutamate exchange","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/citrulline-research/11566871.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"25151a91c1f832fb2e3f86421ef070fb3a7c92390b5b1e7c0038e1db1d6a0734\", \"start_char\": 0, \"end_char\": 1249, \"text_sha256\": \"25151a91c1f832fb2e3f86421ef070fb3a7c92390b5b1e7c0038e1db1d6a0734\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Reconstituted transporter and transfected-cell assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Aspartate exchange for glutamate plus proton; external calcium stimulation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cell and liposome experiments; no evidence that calcium supplementation corrects citrin deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Citrulline research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"citrulline","display_name":"L-Citrulline","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human citrin and aralar proteins","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Moving aspartate between compartments helps connect nitrogen handling and redox metabolism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[citrulline-p11566871] Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria. (2001). https://pubmed.ncbi.nlm.nih.gov/11566871/ DOI: 10.1093/emboj/20.18.5060","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Inner mitochondrial membrane transport; malate-aspartate shuttle","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"eba72b28-1d87-5a06-bea4-db093ac9d3ef","evidence_kind":"source_excerpt","locator":"Lines 359-370","start_line":359,"end_line":370,"excerpt":"### citrulline-citrin-aspartate\nReconstituted citrin exchanged aspartate for glutamate plus a proton.\nCondition category: normal\nnutrient_topic: Citrulline research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Moving aspartate between compartments helps connect nitrogen handling and redox metabolism.\norganism: Human citrin and aralar proteins\ntissue_or_cell_type: Inner mitochondrial membrane transport; malate-aspartate shuttle\nexperimental_model: Reconstituted transporter and transfected-cell assays\nlimitations: Cell and liposome experiments; no evidence that calcium supplementation corrects citrin deficiency.\nexposure: Aspartate exchange for glutamate plus proton; external calcium stimulation\nevidence_span: {\"source_cache\": \"artifacts/citrulline-research/11566871.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"25151a91c1f832fb2e3f86421ef070fb3a7c92390b5b1e7c0038e1db1d6a0734\", \"start_char\": 0, \"end_char\": 1249, \"text_sha256\": \"25151a91c1f832fb2e3f86421ef070fb3a7c92390b5b1e7c0038e1db1d6a0734\"}\n[citrulline-p11566871] Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria. 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