{"id":"fcf84d81-14ce-5bca-be94-d270c44950e8","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:pooled-trials-show-lower-hdl-cholesterol-at-low-dose","predicate":"reduces","statement":"At relatively low total dosage the pooled mean difference in high-density lipoprotein cholesterol was -2.76 against control.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"989df323-ab7e-5c8a-bec3-19e3b835bf5a","mechanism_event_label":"At relatively low total dosage the pooled mean difference in high-density lipoprotein cholesterol was -2.76 against control.","subject":{"id":"e8eb9bb4-3c6f-5e96-a968-a6d1fece71e7","slug":"nattokinase-supplement","display_name":"Commercial nattokinase supplement, composition study-specific","entity_type_key":"chemical_species"},"object":{"id":"b98b9c42-3021-51d6-bfea-4335603c85f1","slug":"blood-hdl-cholesterol","display_name":"Blood high-density lipoprotein cholesterol concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"989df323-ab7e-5c8a-bec3-19e3b835bf5a","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:pooled-trials-show-lower-hdl-cholesterol-at-low-dose-event","event_type":"observed_intervention","label":"At relatively low total dosage the pooled mean difference in high-density lipoprotein cholesterol was -2.76 against control.","description":"Blood lipids","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e8eb9bb4-3c6f-5e96-a968-a6d1fece71e7","slug":"nattokinase-supplement","display_name":"Commercial nattokinase supplement, composition study-specific","entity_type_key":"chemical_species"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b98b9c42-3021-51d6-bfea-4335603c85f1","slug":"blood-hdl-cholesterol","display_name":"Blood high-density lipoprotein cholesterol concentration","entity_type_key":"cellular_process"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Trial durations differ","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. 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Every reference in that document was resolved against live PubMed with its abstract read and its DOI cross-checked on 2026-09-23, and the EFSA novel-food opinion was retrieved and read in full. That check corrected two PMIDs that pointed at unrelated papers, two DOIs, and two papers recorded as carrying no erratum that do carry one; it also reversed three findings the supplied document had stated backwards. Two papers carry a published correction, recorded as such and not as a retraction. Three sources are not indexed in PubMed and are cited by what they have. Laboratory lineages are recorded, so the four papers from one group, the three from another and the two readings of a single applicant dossier cannot be counted as separate lines of support. Study-specific doses, units, populations and limitations retained; activity units are never converted between systems. 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