{"id":"fcdc7b4d-46a2-58dc-ac7f-238b7c48cbbb","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-pgp-efflux:signed","predicate":"reduces_efflux_associated_with","statement":"Myricetin increased rhodamine-123 accumulation in P-glycoprotein-overexpressing human MCF-7/ADR cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"ab152a78-3473-5058-b607-87501ad44af7","mechanism_event_label":"Less export can increase intracellular probe retention.","subject":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"object":{"id":"c6139b52-4140-5622-9e33-1f6c6385265d","slug":"abcb1","display_name":"Human P-glycoprotein / ABCB1 / MDR1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"ab152a78-3473-5058-b607-87501ad44af7","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-pgp-efflux-event","event_type":"observed_relationship","label":"Less export can increase intracellular probe retention.","description":"Myricetin increased rhodamine-123 accumulation in P-glycoprotein-overexpressing human MCF-7/ADR cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c6139b52-4140-5622-9e33-1f6c6385265d","slug":"abcb1","display_name":"Human P-glycoprotein / ABCB1 / MDR1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Drug-resistant human breast-cell model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Functional probe result, not proof of selective direct binding or human intestinal inhibition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Less export can increase intracellular probe retention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of myricetin on the bioavailability of carvedilol in rats. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22132944/ · DOI 10.3109/13880209.2011.611141","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"377d91f1-6a29-5a08-af87-e5862b34d5dd","evidence_kind":"source_excerpt","locator":"Lines 236-242","start_line":236,"end_line":242,"excerpt":"## myricetin-pgp-efflux\nLess export can increase intracellular probe retention.\nMyricetin increased rhodamine-123 accumulation in P-glycoprotein-overexpressing human MCF-7/ADR cells.\nModel: Drug-resistant human breast-cell model.\nLimitations: Functional probe result, not proof of selective direct binding or human intestinal inhibition.\nEvidence access: Primary abstract\nEffects of myricetin on the bioavailability of carvedilol in rats. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22132944/ · DOI 10.3109/13880209.2011.611141","model_system":"Drug-resistant human breast-cell model.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"58045cd9-3b27-5469-bb4b-e1c6a9bdca34","stable_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"0abf512275cf3aae9e4ec8544f1cde97e0155d0cfb5be12a193cdd5a898386a7","revision_id":"422e342f-a55c-5e73-ba98-43df560f49b9","review_status":"unverified_draft","notes":""}}],"relations":[{"id":"9034b4ab-60fe-5609-bbed-e12ccf1c6f4f","relation_type":"supersedes","notes":"Direction was left unset on the original while the same record stated it twice: the predicate reduces_efflux_associated_with and the plain-language line 'Less export can increase intracellular probe retention.' The statement reports the probe accumulating, which is the inverse readout of the transporter activity the claim is about, so no text rule can sign it. Replacement carries direction negative on P-glycoprotein activity; statement, contexts and evidence are unchanged.","source_claim_id":"fcdc7b4d-46a2-58dc-ac7f-238b7c48cbbb","source_claim_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-pgp-efflux:signed","source_statement":"Myricetin increased rhodamine-123 accumulation in P-glycoprotein-overexpressing human MCF-7/ADR cells.","target_claim_id":"21eaa45c-ac27-5b25-a1f5-dde5123cec1b","target_claim_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-pgp-efflux","target_statement":"Myricetin increased rhodamine-123 accumulation in P-glycoprotein-overexpressing human MCF-7/ADR cells."}],"conflicts":[],"corrections":[{"id":"95bbee6f-bc90-5c53-9955-a6c4388dcfd9","title":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-pgp-efflux:signed / 8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-pgp-efflux","kind":"supersedes","status":"corrected","why":"The ledger explicitly records that ‘Myricetin increased rhodamine-123 accumulation in P-glycoprotein-overexpressing human MCF-7/ADR cells.’ supersedes ‘Myricetin increased rhodamine-123 accumulation in P-glycoprotein-overexpressing human MCF-7/ADR cells.’. Direction was left unset on the original while the same record stated it twice: the predicate reduces_efflux_associated_with and the plain-language line 'Less export can increase intracellular probe retention.' The statement reports the probe accumulating, which is the inverse readout of the transporter activity the claim is about, so no text rule can sign it. Replacement carries direction negative on P-glycoprotein activity; statement, contexts and evidence are unchanged.","resolution":"The earlier statement is superseded; both versions are retained in correction history.","created_at":"2026-10-02 02:42:45","record_type":"correction","display_label":"Correction history","record_url":"/corrections/95bbee6f-bc90-5c53-9955-a6c4388dcfd9","sides":[{"conflict_id":"95bbee6f-bc90-5c53-9955-a6c4388dcfd9","ordinal":0,"label":"Related statement","revision_id":"422e342f-a55c-5e73-ba98-43df560f49b9","start_line":236,"end_line":242,"quote":"## myricetin-pgp-efflux\nLess export can increase intracellular probe retention.\nMyricetin increased rhodamine-123 accumulation in P-glycoprotein-overexpressing human MCF-7/ADR cells.\nModel: Drug-resistant human breast-cell model.\nLimitations: Functional probe result, not proof of selective direct binding or human intestinal inhibition.\nEvidence access: Primary abstract\nEffects of myricetin on the bioavailability of carvedilol in rats. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22132944/ · DOI 10.3109/13880209.2011.611141","source_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","source_title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","claim_ids":["fcdc7b4d-46a2-58dc-ac7f-238b7c48cbbb"]},{"conflict_id":"95bbee6f-bc90-5c53-9955-a6c4388dcfd9","ordinal":1,"label":"Opposing statement","revision_id":"422e342f-a55c-5e73-ba98-43df560f49b9","start_line":236,"end_line":242,"quote":"## myricetin-pgp-efflux\nLess export can increase intracellular probe retention.\nMyricetin increased rhodamine-123 accumulation in P-glycoprotein-overexpressing human MCF-7/ADR cells.\nModel: Drug-resistant human breast-cell model.\nLimitations: Functional probe result, not proof of selective direct binding or human intestinal inhibition.\nEvidence access: Primary abstract\nEffects of myricetin on the bioavailability of carvedilol in rats. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22132944/ · DOI 10.3109/13880209.2011.611141","source_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","source_title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","claim_ids":["21eaa45c-ac27-5b25-a1f5-dde5123cec1b"]}]}],"research":null}