{"id":"fc69aea3-f95a-55f1-bf1b-4238b87daceb","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-kb-repletion","predicate":"repletion_restores","statement":"Adding tryptophan reversed IFN-gamma-associated growth suppression in KB cells in a dose- and time-dependent manner.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"496623f8-b6e4-5965-9124-d8e413913399","mechanism_event_label":"Replacement helped where deprivation was the limiting mechanism.","subject":{"id":"769339cb-213b-559e-acc0-07ed00368b94","slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"},"object":{"id":"68d47aa4-c2a4-5a9b-8548-912dc479f43d","slug":"human-kb-proliferation","display_name":"Proliferation of human KB cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"496623f8-b6e4-5965-9124-d8e413913399","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-kb-repletion-event","event_type":"observed_relationship","label":"Replacement helped where deprivation was the limiting mechanism.","description":"Adding tryptophan reversed IFN-gamma-associated growth suppression in KB cells in a dose- and time-dependent manner.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"769339cb-213b-559e-acc0-07ed00368b94","slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"68d47aa4-c2a4-5a9b-8548-912dc479f43d","slug":"human-kb-proliferation","display_name":"Proliferation of human KB cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"393e7fb8-8b09-5b6a-b7e4-a31a78b4fcfb","slug":"ifng","display_name":"Human interferon gamma / IFNG","entity_type_key":"cytokine"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9edba4aa-c2f5-5a4e-9750-15e9a38b1822","slug":"ido1","display_name":"Human indoleamine 2,3-dioxygenase 1 / IDO1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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