{"id":"fc645d0f-da49-5f3c-ada9-35bcda1f737d","stable_key":"8c946991-97f0-55ee-8df0-00e67621962f:nad-plus-hmga-nampt","predicate":"upregulates","statement":"HMGA1-dependent NAMPT expression contributed to increased NAD metabolism and the proinflammatory secretory phenotype in oncogene-induced senescent human IMR90 fibroblasts.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"126b30b6-fb4a-5aa2-a6bd-45f2acba0351","mechanism_event_label":"A gene regulator can increase NAD salvage in a cell that is already senescent.","subject":{"id":"afd1be2a-cfc9-561f-b56b-45ca285c1637","slug":"hmga1","display_name":"Human HMGA1","entity_type_key":"protein"},"object":{"id":"8272125c-0d87-5920-9dae-7409b797bbfa","slug":"nampt","display_name":"Human nicotinamide phosphoribosyltransferase / NAMPT","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"126b30b6-fb4a-5aa2-a6bd-45f2acba0351","stable_key":"8c946991-97f0-55ee-8df0-00e67621962f:nad-plus-hmga-nampt-event","event_type":"observed_relationship","label":"A gene regulator can increase NAD salvage in a cell that is already senescent.","description":"HMGA1-dependent NAMPT expression contributed to increased NAD metabolism and the proinflammatory secretory phenotype in oncogene-induced senescent human IMR90 fibroblasts.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"afd1be2a-cfc9-561f-b56b-45ca285c1637","slug":"hmga1","display_name":"Human HMGA1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8272125c-0d87-5920-9dae-7409b797bbfa","slug":"nampt","display_name":"Human nicotinamide phosphoribosyltransferase / NAMPT","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"283ed24b-06a1-50aa-9281-df3bac6ce37e","slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"c46cbbd3-c7f6-5b16-8259-1da4b7db0f63","slug":"human-imr90-proinflammatory-sasp","display_name":"Proinflammatory SASP in human IMR90 fibroblasts","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human fibroblast oncogene-induced senescence with genetic perturbations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Senescence type matters; replicative and mitochondrial-dysfunction senescence need not share this pattern.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"NAD+ collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A gene regulator can increase NAD salvage in a cell that is already senescent.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"NAD+ metabolism governs the proinflammatory senescence-associated secretome. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30778219/ · DOI 10.1038/s41556-019-0287-4","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4bab1895-9f26-523b-b69f-9e21405b0093","evidence_kind":"source_excerpt","locator":"Lines 148-154","start_line":148,"end_line":154,"excerpt":"## nad-plus-hmga-nampt\nA gene regulator can increase NAD salvage in a cell that is already senescent.\nHMGA1-dependent NAMPT expression contributed to increased NAD metabolism and the proinflammatory secretory phenotype in oncogene-induced senescent human IMR90 fibroblasts.\nModel: Human fibroblast oncogene-induced senescence with genetic perturbations.\nLimitations: Senescence type matters; replicative and mitochondrial-dysfunction senescence need not share this pattern.\nEvidence access: Primary full text\nNAD+ metabolism governs the proinflammatory senescence-associated secretome. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30778219/ · DOI 10.1038/s41556-019-0287-4","model_system":"Human fibroblast oncogene-induced senescence with genetic perturbations.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f59aa302-d463-5462-876f-e21e64861eac","stable_key":"import-8c946991-97f0-55ee-8df0-00e67621962f","title":"NAD+: compartmental supply, consumption and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"9f5324d0d652c80ad630b3100e28ce34cd2ce260ea2e1324332a4262ce72ae09","revision_id":"0e07909c-e8bc-5950-bafc-61371d9d6412","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}