{"id":"fc2ccc31-cd89-5fab-87ed-a91d06ad34cc","stable_key":"27e0c1cf-7726-5164-8b15-27a631584cd0:choline-bhmt-snp-null","predicate":"has_no_detected_association","statement":"The BHMT rs3733890 comparison did not show an association with susceptibility in this depletion study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"84e02b09-86e4-54e4-9a87-f80561732791","mechanism_event_label":"Not every tested variant predicted the clinical response.","subject":{"id":"e9005398-a048-55b2-b69d-e4b7ca4d8ac2","slug":"bhmt-rs3733890-2006","display_name":"BHMT rs3733890 genotype comparison in the 2006 depletion study","entity_type_key":"gene"},"object":{"id":"57aaf728-3b0f-5dda-b2e4-69ddef823b6b","slug":"human-choline-depletion-organ-dysfunction","display_name":"Fatty liver or muscle damage during controlled human choline depletion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"84e02b09-86e4-54e4-9a87-f80561732791","stable_key":"27e0c1cf-7726-5164-8b15-27a631584cd0:choline-bhmt-snp-null-event","event_type":"observed_intervention","label":"Not every tested variant predicted the clinical response.","description":"The BHMT rs3733890 comparison did not show an association with susceptibility in this depletion study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e9005398-a048-55b2-b69d-e4b7ca4d8ac2","slug":"bhmt-rs3733890-2006","display_name":"BHMT rs3733890 genotype comparison in the 2006 depletion study","entity_type_key":"gene"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"57aaf728-3b0f-5dda-b2e4-69ddef823b6b","slug":"human-choline-depletion-organ-dysfunction","display_name":"Fatty liver or muscle damage during controlled human choline depletion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/choline-research/16816108.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"555f2ace5850ed1fce7061ce91c5133cac7d92c29fdab192b0aa595f9dd390b1\", \"start_char\": 0, \"end_char\": 1424, \"text_sha256\": \"555f2ace5850ed1fce7061ce91c5133cac7d92c29fdab192b0aa595f9dd390b1\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Genotype association within the controlled depletion cohort","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Common PEMT/CHDH/BHMT variants during low-choline feeding","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small candidate-gene study; does not support deterministic recommendations from one SNP. Shares participants with related depletion publications.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Choline research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"choline","display_name":"Choline","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Not every tested variant predicted the clinical response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[choline-p16816108] Common genetic polymorphisms affect the human requirement for the nutrient choline. 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Shares participants with related depletion publications.\nexposure: Common PEMT/CHDH/BHMT variants during low-choline feeding\nevidence_span: {\"source_cache\": \"artifacts/choline-research/16816108.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"555f2ace5850ed1fce7061ce91c5133cac7d92c29fdab192b0aa595f9dd390b1\", \"start_char\": 0, \"end_char\": 1424, \"text_sha256\": \"555f2ace5850ed1fce7061ce91c5133cac7d92c29fdab192b0aa595f9dd390b1\"}\n[choline-p16816108] Common genetic polymorphisms affect the human requirement for the nutrient choline. (2006). https://pubmed.ncbi.nlm.nih.gov/16816108/ DOI: 10.1096/fj.06-5734com","model_system":"Genotype association within the controlled depletion cohort","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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