{"id":"fbfa4b6b-0636-586c-ba85-1c6612ab2161","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-ba-work","predicate":"increases","statement":"Beta-alanine supplementation increased cycling work at 110% maximum power alongside muscle carnosine loading.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"85f0e0dc-28f6-5d08-80bd-ba5035be2df7","mechanism_event_label":"One trial linked loading with improved high-intensity work.","subject":{"id":"288f19a6-62f0-51fe-8e6d-366388b6b16d","slug":"beta-alanine","display_name":"Beta-alanine","entity_type_key":"small_molecule"},"object":{"id":"ede54f16-ff48-5974-b2b6-cc030772ce04","slug":"human-high-intensity-work-capacity","display_name":"Human high-intensity cycling work capacity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"85f0e0dc-28f6-5d08-80bd-ba5035be2df7","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-ba-work-event","event_type":"observed_relationship","label":"One trial linked loading with improved high-intensity work.","description":"Beta-alanine supplementation increased cycling work at 110% maximum power alongside muscle carnosine loading.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"288f19a6-62f0-51fe-8e6d-366388b6b16d","slug":"beta-alanine","display_name":"Beta-alanine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ede54f16-ff48-5974-b2b6-cc030772ce04","slug":"human-high-intensity-work-capacity","display_name":"Human high-intensity cycling work capacity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"644cc445-599f-50c6-9356-b714a5b71e9c","slug":"human-muscle-carnosine-content","display_name":"Human skeletal-muscle carnosine content","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human cycling and muscle-biopsy study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Parallel changes do not isolate proton buffering as the sole cause.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Carnosine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"One trial linked loading with improved high-intensity work.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. · 2007 · https://pubmed.ncbi.nlm.nih.gov/16868650/ · DOI 10.1007/s00726-006-0364-4","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c0a7d48e-5288-574a-b122-90267b20e510","evidence_kind":"source_excerpt","locator":"Lines 212-218","start_line":212,"end_line":218,"excerpt":"## carnosine-ba-work\nOne trial linked loading with improved high-intensity work.\nBeta-alanine supplementation increased cycling work at 110% maximum power alongside muscle carnosine loading.\nModel: Human cycling and muscle-biopsy study.\nLimitations: Parallel changes do not isolate proton buffering as the sole cause.\nEvidence access: Primary abstract\nInfluence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. · 2007 · https://pubmed.ncbi.nlm.nih.gov/16868650/ · DOI 10.1007/s00726-006-0364-4","model_system":"Human cycling and muscle-biopsy study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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