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The NDI1 rescue is strong evidence that the effects run through complex I in this model, not evidence of an antitumour indication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Metformin research collection; topical membership is not evidence of a direct clinical effect, and pharmacological exposure is not dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"metformin","display_name":"Metformin","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human cells; mouse in vivo","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Slowing the chain also changed how the cell reads low oxygen.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[metformin-p24843020] Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. 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The NDI1 rescue is strong evidence that the effects run through complex I in this model, not evidence of an antitumour indication.\nexposure: Metformin in the presence and absence of glucose; NDI1 overexpression\nevidence_span: {\"source_cache\": \"artifacts/metformin-research/24843020.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"21403805272b0d702f0f60887d805b1e52b4ce87a9335fcde1d34cefda8b16ae\", \"start_char\": 0, \"end_char\": 1142, \"text_sha256\": \"21403805272b0d702f0f60887d805b1e52b4ce87a9335fcde1d34cefda8b16ae\"}\n[metformin-p24843020] Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. 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