{"id":"faaad9bc-a07a-55f1-81f9-64084f61407d","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-cyp-inhibition","predicate":"weakly_inhibits","statement":"Astaxanthin weakly inhibited CYP2C19 in the in-vitro enzyme panel, with IC50 16.2 micromolar and no time-dependent IC50 shift.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7cea0a5f-efb4-502d-b917-0082cd565ff0","mechanism_event_label":"An enzyme effect required concentrations above reported human blood exposure.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"cc080b54-fd5d-5cc0-930e-2cb86c116c68","slug":"cyp2c19","display_name":"Human cytochrome P450 2C19","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"7cea0a5f-efb4-502d-b917-0082cd565ff0","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-cyp-inhibition-event","event_type":"observed_relationship","label":"An enzyme effect required concentrations above reported human blood exposure.","description":"Astaxanthin weakly inhibited CYP2C19 in the in-vitro enzyme panel, with IC50 16.2 micromolar and no time-dependent IC50 shift.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cc080b54-fd5d-5cc0-930e-2cb86c116c68","slug":"cyp2c19","display_name":"Human cytochrome P450 2C19","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"In-vitro CYP panel and exposure comparison in the primary study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"An inhibition assay differs from hepatocyte induction; neither establishes a clinically important interaction at ordinary oral exposures.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"An enzyme effect required concentrations above reported human blood exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Inhibitory effects of astaxanthin, β-cryptoxanthin, canthaxanthin, lutein, and zeaxanthin on cytochrome P450 enzyme activities. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23669408/ · DOI 10.1016/j.fct.2013.04.053","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f84a8dc5-fce0-53c0-ba6b-79907beee9ca","evidence_kind":"source_excerpt","locator":"Lines 142-148","start_line":142,"end_line":148,"excerpt":"## astaxanthin-cyp-inhibition\nAn enzyme effect required concentrations above reported human blood exposure.\nAstaxanthin weakly inhibited CYP2C19 in the in-vitro enzyme panel, with IC50 16.2 micromolar and no time-dependent IC50 shift.\nModel: In-vitro CYP panel and exposure comparison in the primary study.\nLimitations: An inhibition assay differs from hepatocyte induction; neither establishes a clinically important interaction at ordinary oral exposures.\nEvidence access: Primary abstract\nInhibitory effects of astaxanthin, β-cryptoxanthin, canthaxanthin, lutein, and zeaxanthin on cytochrome P450 enzyme activities. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23669408/ · DOI 10.1016/j.fct.2013.04.053","model_system":"In-vitro CYP panel and exposure comparison in the primary study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"98640e32f62e6c0387578165342ad21b3d2325701fcfdbb5c48886c783040e5e","revision_id":"a82757ce-1feb-582c-a5fc-f7de36308f1f","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}