{"id":"fa318ae7-6abe-501a-bc42-47b745ed647b","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-10-human-free","predicate":"produces_detectable_parent","statement":"Free 10-gingerol peaked at 9.5 +/- 2.2 ng/mL approximately one hour after ginger extract ingestion.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"a09307d4-efd6-5bc4-9e6a-d872377ba2d8","mechanism_event_label":"Free 10-gingerol peaked at 9.5 +/- 2.2 ng/mL approximately one hour after ginger extract ingestion.","subject":{"id":"000525c3-a599-5da3-98a9-d70875a53a6d","slug":"ginger-2011-pk-preparation","display_name":"Ginger extract in the 2011 human pharmacokinetic study","entity_type_key":"small_molecule"},"object":{"id":"71ebdb4c-e79a-5aed-a00d-a3b213347eb1","slug":"human-plasma-free-10-gingerol","display_name":"Unconjugated 10-gingerol in human plasma","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a09307d4-efd6-5bc4-9e6a-d872377ba2d8","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-10-human-free-event","event_type":"observed_relationship","label":"Free 10-gingerol peaked at 9.5 +/- 2.2 ng/mL approximately one hour after ginger extract ingestion.","description":"Free 10-gingerol peaked at 9.5 +/- 2.2 ng/mL approximately one hour after ginger extract ingestion.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"000525c3-a599-5da3-98a9-d70875a53a6d","slug":"ginger-2011-pk-preparation","display_name":"Ginger extract in the 2011 human pharmacokinetic study","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"71ebdb4c-e79a-5aed-a00d-a3b213347eb1","slug":"human-plasma-free-10-gingerol","display_name":"Unconjugated 10-gingerol in human plasma","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bf4fa054-0b02-5fc2-82dd-2e53b36033b3","slug":"10-gingerol","display_name":"10-Gingerol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Ginger extract 2 g; LC-MS/MS lower quantification limit 2-5 ng/mL","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Sampling 0.25-24 h for parent analytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation, not universally established human effects","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Healthy human volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Food/product and analytical sensitivity differ from the 2008 study. Non-detection is not proof of zero absorption.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Gingerols collection; each molecular form and experimental preparation remains explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gingerols","display_name":"Gingerols","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Healthy human volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Free 10-gingerol peaked at 9.5 +/- 2.2 ng/mL approximately one hour after ginger extract ingestion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Examination of the pharmacokinetics of active ingredients of ginger in humans. (2011). https://pubmed.ncbi.nlm.nih.gov/21638149/ DOI: 10.1208/s12248-011-9286-5","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral mixed ginger extract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Plasma","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"24253828-6afe-5a53-aea9-b0446682c888","evidence_kind":"source_excerpt","locator":"Lines 404-413","start_line":404,"end_line":413,"excerpt":"## gingerols-10-human-free\nFree 10-gingerol peaked at 9.5 +/- 2.2 ng/mL approximately one hour after ginger extract ingestion.\nModel/species: Healthy human volunteers\nTissue: Plasma\nExposure: Ginger extract 2 g; LC-MS/MS lower quantification limit 2-5 ng/mL\nRoute: Oral mixed ginger extract\nDuration: Sampling 0.25-24 h for parent analytes\nLimits: Food/product and analytical sensitivity differ from the 2008 study. Non-detection is not proof of zero absorption.\nPrimary reference: Examination of the pharmacokinetics of active ingredients of ginger in humans. (2011). https://pubmed.ncbi.nlm.nih.gov/21638149/ DOI: 10.1208/s12248-011-9286-5\nAccess: Primary PubMed abstract.","model_system":"Healthy human volunteers","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived synthesis span with its primary citation; original paraphrase, not a claimed publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1107d60b-8e2d-55d7-8f5d-5612c49aa7dc","stable_key":"import-fd7915ff-856d-56c2-a118-4989693a7644","title":"Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. 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