{"id":"f9ffa907-c527-5bda-a82a-7d067e357b9f","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-glucose-null","predicate":"did_not_significantly_change","statement":"Despite slower estimated emptying, the post-meal glucose profile was not significantly changed.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"887a8f57-1b47-58af-affa-807eb087bfc3","mechanism_event_label":"A slower stomach did not automatically produce a lower glucose response.","subject":{"id":"5449346d-7614-5c4b-bbd2-03fb4dd71aeb","slug":"pectin","display_name":"Pectin, structurally heterogeneous plant polysaccharides","entity_type_key":"chemical_species"},"object":{"id":"d2777d76-e518-54dc-8907-f170cbc10a03","slug":"postmeal-glucose-profile","display_name":"Human post-meal glucose profile","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"887a8f57-1b47-58af-affa-807eb087bfc3","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-glucose-null-event","event_type":"observed_intervention","label":"A slower stomach did not automatically produce a lower glucose response.","description":"Despite slower estimated emptying, the post-meal glucose profile was not significantly changed.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5449346d-7614-5c4b-bbd2-03fb4dd71aeb","slug":"pectin","display_name":"Pectin, structurally heterogeneous plant polysaccharides","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d2777d76-e518-54dc-8907-f170cbc10a03","slug":"postmeal-glucose-profile","display_name":"Human post-meal glucose profile","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/pectin-research/17880369.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c07bb2fe0617daf1d3a1af1725b351e19fbfec477851697c7b575d905aa1b1c7\", \"start_char\": 0, \"end_char\": 2164, \"text_sha256\": \"c07bb2fe0617daf1d3a1af1725b351e19fbfec477851697c7b575d905aa1b1c7\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Three-meal comparison in ten healthy men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"450-kcal, 500-mL meal with 5.2 g pectin, agar, or control; 13C-acetate breath test","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A gastric-emptying breath-test estimate is not direct proof of a specific glucose-enzyme inhibition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pectin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pectin","display_name":"Pectin, structurally heterogeneous plant polysaccharides","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A slower stomach did not automatically produce a lower glucose response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[pectin-p17880369] Effects of agar and pectin on gastric emptying and post-prandial glycaemic profiles in healthy human volunteers. (2007). https://pubmed.ncbi.nlm.nih.gov/17880369/ DOI: 10.1111/j.1440-1681.2007.04706.x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Gastric emptying and post-meal glucose","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2d418cb6-2076-5df9-b6be-26e0b66b289a","evidence_kind":"source_excerpt","locator":"Lines 815-826","start_line":815,"end_line":826,"excerpt":"### pectin-glucose-null\nDespite slower estimated emptying, the post-meal glucose profile was not significantly changed.\nCondition category: normal\nnutrient_topic: Pectin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A slower stomach did not automatically produce a lower glucose response.\norganism: Homo sapiens\ntissue_or_cell_type: Gastric emptying and post-meal glucose\nexperimental_model: Three-meal comparison in ten healthy men\nlimitations: A gastric-emptying breath-test estimate is not direct proof of a specific glucose-enzyme inhibition.\nexposure: 450-kcal, 500-mL meal with 5.2 g pectin, agar, or control; 13C-acetate breath test\nevidence_span: {\"source_cache\": \"artifacts/pectin-research/17880369.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c07bb2fe0617daf1d3a1af1725b351e19fbfec477851697c7b575d905aa1b1c7\", \"start_char\": 0, \"end_char\": 2164, \"text_sha256\": \"c07bb2fe0617daf1d3a1af1725b351e19fbfec477851697c7b575d905aa1b1c7\"}\n[pectin-p17880369] Effects of agar and pectin on gastric emptying and post-prandial glycaemic profiles in healthy human volunteers. 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