{"id":"f9afa3f1-429b-54ef-8f16-c8b72157ee0e","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:casr-calcium-pth-suppression","predicate":"inhibits","statement":"CaSR potentiation by NPS R-568 strengthens extracellular-calcium-mediated inhibition of PTH secretion in bovine parathyroid cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"046dccf3-df51-593d-bf64-157b631d3351","mechanism_event_label":"Greater calcium-sensor activation reduces hormone release.","subject":{"id":"1c0d5c58-d358-5501-9bdf-8999bcf79fd4","slug":"casr","display_name":"Calcium-sensing receptor / CaSR","entity_type_key":"protein"},"object":{"id":"003d1a6f-e672-5a4e-b78b-fac58daaa987","slug":"pth-secretion","display_name":"Parathyroid hormone secretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"046dccf3-df51-593d-bf64-157b631d3351","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:casr-calcium-pth-suppression-event","event_type":"biochemical_relationship","label":"Greater calcium-sensor activation reduces hormone release.","description":"CaSR potentiation by NPS R-568 strengthens extracellular-calcium-mediated inhibition of PTH secretion in bovine parathyroid cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1c0d5c58-d358-5501-9bdf-8999bcf79fd4","slug":"casr","display_name":"Calcium-sensing receptor / CaSR","entity_type_key":"protein"},"role":"receptor","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"ligand","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5ba31821-7b29-546a-9a61-64d836cbe22b","slug":"nps-r568","display_name":"NPS R-568","entity_type_key":"small_molecule"},"role":"experimental_modulator","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e162b0ab-1449-5471-b3c3-4638a0fa3a96","slug":"pth","display_name":"Parathyroid hormone / PTH","entity_type_key":"protein"},"role":"secreted_hormone","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"003d1a6f-e672-5a4e-b78b-fac58daaa987","slug":"pth-secretion","display_name":"Parathyroid hormone secretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Bovine parathyroid cells and human CaSR-expressing HEK293 cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Pharmacological cell experiment; potentiation required extracellular calcium.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Calcium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Bos taurus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Greater calcium-sensor activation reduces hormone release.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[nemeth1998] Calcimimetics with potent and selective activity on the parathyroid calcium receptor (1998). https://pmc.ncbi.nlm.nih.gov/articles/PMC19959/ DOI: 10.1073/pnas.95.7.4040","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Parathyroid cells","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e9ad22d7-f374-57a5-bed2-df292efb03e3","evidence_kind":"source_excerpt","locator":"Lines 25-34","start_line":25,"end_line":34,"excerpt":"### casr-calcium-pth-suppression\nCaSR potentiation by NPS R-568 strengthens extracellular-calcium-mediated inhibition of PTH secretion in bovine parathyroid cells.\nCondition category: normal\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Greater calcium-sensor activation reduces hormone release.\norganism: Bos taurus\ntissue_or_cell_type: Parathyroid cells\nexperimental_model: Bovine parathyroid cells and human CaSR-expressing HEK293 cells\nlimitations: Pharmacological cell experiment; potentiation required extracellular calcium.\n[nemeth1998] Calcimimetics with potent and selective activity on the parathyroid calcium receptor (1998). https://pmc.ncbi.nlm.nih.gov/articles/PMC19959/ DOI: 10.1073/pnas.95.7.4040","model_system":"Bovine parathyroid cells and human CaSR-expressing HEK293 cells","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [nemeth1998] Calcimimetics with potent and selective activity on the parathyroid calcium receptor (1998). https://pmc.ncbi.nlm.nih.gov/articles/PMC19959/ DOI: 10.1073/pnas.95.7.4040","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3c083fa0-59c6-50e9-af42-678d0e3c1006","stable_key":"import-434e1e27-eb90-583a-956b-62472726ffba","title":"Calcium: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"965c934d6b147f2b62f8d45ce6d7a87681a600bfe5c46a585b4704889afd3fc1","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}