{"id":"f96f4bf7-02f8-5fdf-9eaf-7879962ae64f","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-shuttle-ltp","predicate":"supports","statement":"Enzymatic removal of extracellular L-serine impaired hippocampal long-term potentiation, supporting a role for an intercellular serine supply route.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"464d3fa7-8ce2-5083-b1bf-cb8a7d8a761e","mechanism_event_label":"Removing extracellular precursor can disrupt a downstream signaling response.","subject":{"id":"c882cd0b-9d83-5b07-bd1c-fe4d45657dcb","slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"},"object":{"id":"7fae2cac-0b4c-59cc-bf01-f8ca1067019d","slug":"mouse-hippocampal-serine-ltp","display_name":"Mouse hippocampal serine-shuttle-dependent plasticity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"464d3fa7-8ce2-5083-b1bf-cb8a7d8a761e","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-shuttle-ltp-event","event_type":"observed_relationship","label":"Removing extracellular precursor can disrupt a downstream signaling response.","description":"Enzymatic removal of extracellular L-serine impaired hippocampal long-term potentiation, supporting a role for an intercellular serine supply route.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c882cd0b-9d83-5b07-bd1c-fe4d45657dcb","slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7fae2cac-0b4c-59cc-bf01-f8ca1067019d","slug":"mouse-hippocampal-serine-ltp","display_name":"Mouse hippocampal serine-shuttle-dependent plasticity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7f3bf9f5-b1b1-5381-baa6-72800ceb5436","slug":"d-serine","display_name":"D-Serine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse hippocampal synaptic experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"L-serine supplies D-serine; this is not evidence that L-serine directly substitutes at the NMDAR coagonist site.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Serine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Removing extracellular precursor can disrupt a downstream signaling response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The NMDA receptor activation by d-serine and glycine is controlled by an astrocytic Phgdh-dependent serine shuttle. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31548413/ · DOI 10.1073/pnas.1909458116","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"7c549fe8-60ba-5a1a-8ec6-d376651ba815","evidence_kind":"source_excerpt","locator":"Lines 350-356","start_line":350,"end_line":356,"excerpt":"## l-serine-shuttle-ltp\nRemoving extracellular precursor can disrupt a downstream signaling response.\nEnzymatic removal of extracellular L-serine impaired hippocampal long-term potentiation, supporting a role for an intercellular serine supply route.\nModel: Mouse hippocampal synaptic experiments.\nLimitations: L-serine supplies D-serine; this is not evidence that L-serine directly substitutes at the NMDAR coagonist site.\nEvidence access: Primary abstract\nThe NMDA receptor activation by d-serine and glycine is controlled by an astrocytic Phgdh-dependent serine shuttle. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31548413/ · DOI 10.1073/pnas.1909458116","model_system":"Mouse hippocampal synaptic experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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