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Correlations between Nrf2 and growth factors are associations within treated tissue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"hyperbaric-oxygen","display_name":"Hyperbaric oxygen therapy","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The master switch for antioxidant defence is measurably higher in the treated wound.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[hbot-p31035003] Tissue-specific role of Nrf2 in the treatment of diabetic foot ulcers during hyperbaric oxygen therapy. (2019). https://pubmed.ncbi.nlm.nih.gov/31035003/ DOI: 10.1016/j.freeradbiomed.2019.04.031","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Diabetic foot ulcer tissue","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1c26321e-b30b-5263-8305-1bf79349d632","evidence_kind":"source_excerpt","locator":"Lines 816-827","start_line":816,"end_line":827,"excerpt":"### hbot-nrf2-induction\nTissue levels of Nrf2 and its downstream targets were significantly increased in patients receiving hyperbaric oxygen compared with standard therapy alone.\nCondition category: normal\nnutrient_topic: Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.\nplain_language: The master switch for antioxidant defence is measurably higher in the treated wound.\norganism: Human\ntissue_or_cell_type: Diabetic foot ulcer tissue\nexperimental_model: Randomised comparison of 32 patients receiving standard wound care with or without hyperbaric oxygen, with ulcer tissue biopsies\nlimitations: A small randomised human study with tissue-level molecular endpoints. Correlations between Nrf2 and growth factors are associations within treated tissue.\nexposure: Hyperbaric oxygen with standard wound care for 20 days\nevidence_span: {\"source_cache\": \"artifacts/hbot-research/31035003.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e0b19a857412f1a255ecc82052eb403389bcf5596a562828c04558e1d4354efc\", \"start_char\": 0, \"end_char\": 1966, \"text_sha256\": \"e0b19a857412f1a255ecc82052eb403389bcf5596a562828c04558e1d4354efc\"}\n[hbot-p31035003] Tissue-specific role of Nrf2 in the treatment of diabetic foot ulcers during hyperbaric oxygen therapy. 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