{"id":"f947091d-5e44-593b-b420-95a57342d703","stable_key":"4df6a932-097e-563a-91fe-5dceec471ffd:chloride-saline-chloride","predicate":"increases","statement":"Saline produced sustained hyperchloremia, unlike Plasma-Lyte 148.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8e6a3b03-f9b3-57d1-9037-7cd60920e993","mechanism_event_label":"The chloride content of a large IV fluid load changes blood chemistry.","subject":{"id":"76d56a30-b05a-5515-a475-00bef49615d9","slug":"saline-0-9-percent","display_name":"0.9% sodium chloride intravenous solution","entity_type_key":"chemical_species"},"object":{"id":"47e28f55-b42f-5862-aadf-40e1513680df","slug":"plasma-chloride-concentration","display_name":"Plasma or serum chloride concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8e6a3b03-f9b3-57d1-9037-7cd60920e993","stable_key":"4df6a932-097e-563a-91fe-5dceec471ffd:chloride-saline-chloride-event","event_type":"observed_intervention","label":"The chloride content of a large IV fluid load changes blood chemistry.","description":"Saline produced sustained hyperchloremia, unlike Plasma-Lyte 148.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a3c76578-787f-5465-bbc6-6a8bb874099c","slug":"balanced-crystalloids","display_name":"Balanced crystalloid intravenous solutions (formulation specified per claim)","entity_type_key":"chemical_species"},"role":"comparator","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"76d56a30-b05a-5515-a475-00bef49615d9","slug":"saline-0-9-percent","display_name":"0.9% sodium chloride intravenous solution","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"47e28f55-b42f-5862-aadf-40e1513680df","slug":"plasma-chloride-concentration","display_name":"Plasma or serum chloride concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chloride-research/22580944.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7d2fb56addfe8ab376d6b086ad5d0da5220a0f6ceaa5733612d927ad2edb1814\", \"start_char\": 0, \"end_char\": 1757, \"text_sha256\": \"7d2fb56addfe8ab376d6b086ad5d0da5220a0f6ceaa5733612d927ad2edb1814\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized blinded crossover","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"2 L saline or Plasma-Lyte 148 over one hour","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"IV fluid formulations differ in several components; short-term perfusion is not kidney failure or dietary salt exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chloride research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chloride","display_name":"Chloride","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Twelve healthy adult men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The chloride content of a large IV fluid load changes blood chemistry.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chloride-p22580944] A randomized, controlled, double-blind crossover study on the effects of 2-L infusions of 0.9% saline and plasma-lyte® 148 on renal blood flow velocity and renal cortical tissue perfusion in healthy volunteers. (2012). https://pubmed.ncbi.nlm.nih.gov/22580944/ DOI: 10.1097/sla.0b013e318256be72","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Renal MRI and blood chemistry","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"95c8d503-afc4-5849-9c0d-6826ebe99601","evidence_kind":"source_excerpt","locator":"Lines 965-976","start_line":965,"end_line":976,"excerpt":"### chloride-saline-chloride\nSaline produced sustained hyperchloremia, unlike Plasma-Lyte 148.\nCondition category: normal\nnutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The chloride content of a large IV fluid load changes blood chemistry.\norganism: Twelve healthy adult men\ntissue_or_cell_type: Renal MRI and blood chemistry\nexperimental_model: Randomized blinded crossover\nlimitations: IV fluid formulations differ in several components; short-term perfusion is not kidney failure or dietary salt exposure.\nexposure: 2 L saline or Plasma-Lyte 148 over one hour\nevidence_span: {\"source_cache\": \"artifacts/chloride-research/22580944.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7d2fb56addfe8ab376d6b086ad5d0da5220a0f6ceaa5733612d927ad2edb1814\", \"start_char\": 0, \"end_char\": 1757, \"text_sha256\": \"7d2fb56addfe8ab376d6b086ad5d0da5220a0f6ceaa5733612d927ad2edb1814\"}\n[chloride-p22580944] A randomized, controlled, double-blind crossover study on the effects of 2-L infusions of 0.9% saline and plasma-lyte® 148 on renal blood flow velocity and renal cortical tissue perfusion in healthy volunteers. (2012). https://pubmed.ncbi.nlm.nih.gov/22580944/ DOI: 10.1097/sla.0b013e318256be72","model_system":"Randomized blinded crossover","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [chloride-p22580944] A randomized, controlled, double-blind crossover study on the effects of 2-L infusions of 0.9% saline and plasma-lyte® 148 on renal blood flow velocity and renal cortical tissue perfusion in healthy volunteers. (2012). https://pubmed.ncbi.nlm.nih.gov/22580944/ DOI: 10.1097/sla.0b013e318256be72","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1c2070d5-9f15-5945-b325-d0b49a32c04b","stable_key":"import-4df6a932-097e-563a-91fe-5dceec471ffd","title":"Chloride: transport, acid-base balance, nutrient interactions and loss states (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e32e796f293a3287c6b8f4394881db94cc741ba96e3166e44da2dd14f208f645","revision_id":"8d5fd8ef-db54-5198-a368-23329a02d81b","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}