{"id":"f93964c9-fb01-561d-98cb-943d5b0c15c8","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-tars1-extracellular","predicate":"stimulates","statement":"Exogenous TARS promoted endothelial migration and angiogenesis in culture and chick chorioallantoic membrane assays.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"60b1e54b-1eb3-564a-bd44-df66dd7ad992","mechanism_event_label":"The same enzyme has an extracellular signaling role.","subject":{"id":"42b7656b-93a3-5348-a7cf-775072512653","slug":"tars1","display_name":"Human cytosolic threonyl-tRNA synthetase / TARS1","entity_type_key":"protein"},"object":{"id":"c3ff2573-13f7-5a86-a9eb-ca01d9c75e99","slug":"endothelial-tars-migration-angiogenesis","display_name":"Endothelial migration and angiogenesis following extracellular TARS","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"60b1e54b-1eb3-564a-bd44-df66dd7ad992","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-tars1-extracellular-event","event_type":"observed_relationship","label":"The same enzyme has an extracellular signaling role.","description":"Exogenous TARS promoted endothelial migration and angiogenesis in culture and chick chorioallantoic membrane assays.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"42b7656b-93a3-5348-a7cf-775072512653","slug":"tars1","display_name":"Human cytosolic threonyl-tRNA synthetase / TARS1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c3ff2573-13f7-5a86-a9eb-ca01d9c75e99","slug":"endothelial-tars-migration-angiogenesis","display_name":"Endothelial migration and angiogenesis following extracellular TARS","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fcef4dc2-a7b6-5812-bc33-c8af3d83f4d0","slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human endothelial assays and chick membrane model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Enzyme exposure is not amino-acid supplementation; no claim of dietary cancer causation is made.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Threonine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The same enzyme has an extracellular signaling role.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23425968/ · DOI 10.1038/srep01317","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"46918f66-bb9f-5280-99d6-08f87094b0fb","evidence_kind":"source_excerpt","locator":"Lines 386-392","start_line":386,"end_line":392,"excerpt":"## l-threonine-tars1-extracellular\nThe same enzyme has an extracellular signaling role.\nExogenous TARS promoted endothelial migration and angiogenesis in culture and chick chorioallantoic membrane assays.\nModel: Human endothelial assays and chick membrane model.\nLimitations: Enzyme exposure is not amino-acid supplementation; no claim of dietary cancer causation is made.\nEvidence access: Primary abstract\nSecreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23425968/ · DOI 10.1038/srep01317","model_system":"Human endothelial assays and chick membrane model.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"35396730-235a-537e-8a05-c6ef2960c509","stable_key":"import-97957230-601f-5dec-8524-0812be8fadbf","title":"L-Threonine: translation, intestinal barrier, metabolism and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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