{"id":"f937b1a9-ca37-5489-bb55-1b61ff47dbd5","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-chronic-loss-receptors","predicate":"supports","statement":"Aged Ddo-knockout mice showed reduced synaptic GluN1/GluN2B, altered plasticity and greater vulnerability to phencyclidine-related prepulse-inhibition deficits.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ee98657d-5f82-5638-814d-48799e9fed0e","mechanism_event_label":"Receptor adaptation can reverse the apparent direction of an earlier signaling effect.","subject":{"id":"f3fc3b2e-7748-5a0a-a936-94c47f68a6d2","slug":"mouse-ddo","display_name":"Mouse D-aspartate oxidase / Ddo","entity_type_key":"protein"},"object":{"id":"97fd88aa-dab6-5a0e-b605-27f2b439f8c9","slug":"mouse-hippocampal-synaptic-nmdar","display_name":"Synaptic NMDA receptor availability in mouse hippocampus","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ee98657d-5f82-5638-814d-48799e9fed0e","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-chronic-loss-receptors-event","event_type":"observed_relationship","label":"Receptor adaptation can reverse the apparent direction of an earlier signaling effect.","description":"Aged Ddo-knockout mice showed reduced synaptic GluN1/GluN2B, altered plasticity and greater vulnerability to phencyclidine-related prepulse-inhibition deficits.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f3fc3b2e-7748-5a0a-a936-94c47f68a6d2","slug":"mouse-ddo","display_name":"Mouse D-aspartate oxidase / Ddo","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"97fd88aa-dab6-5a0e-b605-27f2b439f8c9","slug":"mouse-hippocampal-synaptic-nmdar","display_name":"Synaptic NMDA receptor availability in mouse hippocampus","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"0dfaac36-ded6-5591-bacc-aef6e58b1135","slug":"mouse-nmda-receptors","display_name":"Mouse NMDA-type receptors, subunits unresolved","entity_type_key":"protein_complex"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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