{"id":"f8d23068-8514-5ac2-956d-0ca3e3367f9e","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-warburg-hdac","predicate":"inhibits","statement":"In glycolysis-dominant cancerous colonocytes, reduced butyrate utilization allowed accumulation and HDAC inhibition; altering the metabolic state changed the response.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d5e1f9e0-8d78-53dc-9a02-d3936fecfcc1","mechanism_event_label":"How the cell burns fuel changed how strongly butyrate affected gene regulation.","subject":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"object":{"id":"b8af0d0b-a672-535a-96b1-d9d9abe86146","slug":"human-butyrate-hdac-assay","display_name":"Human colonic-cell HDAC activity in butyrate experiments; isoforms unresolved","entity_type_key":"protein_state"},"evidence_count":1,"mechanism_event":{"id":"d5e1f9e0-8d78-53dc-9a02-d3936fecfcc1","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-warburg-hdac-event","event_type":"observed_relationship","label":"How the cell burns fuel changed how strongly butyrate affected gene regulation.","description":"In glycolysis-dominant cancerous colonocytes, reduced butyrate utilization allowed accumulation and HDAC inhibition; altering the metabolic state changed the response.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b8af0d0b-a672-535a-96b1-d9d9abe86146","slug":"human-butyrate-hdac-assay","display_name":"Human colonic-cell HDAC activity in butyrate experiments; isoforms unresolved","entity_type_key":"protein_state"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human colonic-cell comparisons and metabolic manipulation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A cell-state mechanism is not proof that all tumors respond alike or that dietary butyrate treats cancer.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"How the cell burns fuel changed how strongly butyrate affected gene regulation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23063526/ · DOI 10.1016/j.molcel.2012.08.033","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"56ae8aed-4576-5f5f-9e08-29ec8bd55677","evidence_kind":"source_excerpt","locator":"Lines 190-196","start_line":190,"end_line":196,"excerpt":"## butyrate-warburg-hdac\nHow the cell burns fuel changed how strongly butyrate affected gene regulation.\nIn glycolysis-dominant cancerous colonocytes, reduced butyrate utilization allowed accumulation and HDAC inhibition; altering the metabolic state changed the response.\nModel: Human colonic-cell comparisons and metabolic manipulation.\nLimitations: A cell-state mechanism is not proof that all tumors respond alike or that dietary butyrate treats cancer.\nEvidence access: Primary abstract\nThe Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23063526/ · DOI 10.1016/j.molcel.2012.08.033","model_system":"Human colonic-cell comparisons and metabolic manipulation.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"33205bb8-dcbe-5d2c-afca-86075d7748d1","stable_key":"import-104835a3-b891-5dc4-a6bb-42ab7c6f96c4","title":"Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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