{"id":"f8cabd6e-da51-5777-beda-33fe60751556","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-pantethine-ldl-2014","predicate":"reduces","statement":"The 32-person trial reported LDL-C about 11% below baseline with pantethine at week 16 versus a 3% increase with placebo; the week-16 comparison was significant (P=0.006).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"f92250e8-82f9-5822-8a3f-3d2fac501a54","mechanism_event_label":"The smaller trial also found lower LDL, under its own study conditions.","subject":{"id":"c0600873-c581-5429-91cb-414f179823ce","slug":"pantethine","display_name":"Pantethine","entity_type_key":"small_molecule"},"object":{"id":"ac5f5914-4824-5f9b-93c7-a6b5a52b53af","slug":"ldl-cholesterol-concentration","display_name":"LDL cholesterol concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f92250e8-82f9-5822-8a3f-3d2fac501a54","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-pantethine-ldl-2014-event","event_type":"observed_intervention","label":"The smaller trial also found lower LDL, under its own study conditions.","description":"The 32-person trial reported LDL-C about 11% below baseline with pantethine at week 16 versus a 3% increase with placebo; the week-16 comparison was significant (P=0.006).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c0600873-c581-5429-91cb-414f179823ce","slug":"pantethine","display_name":"Pantethine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ac5f5914-4824-5f9b-93c7-a6b5a52b53af","slug":"ldl-cholesterol-concentration","display_name":"LDL cholesterol concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary indexed abstract; full article retrieval was unavailable.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized triple-blind placebo- and diet-controlled trial in 32 adults eligible for statin therapy under the study criteria","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Pantethine 600 mg/day for weeks 1–8 and 900 mg/day for weeks 9–16.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small short trial with industry-associated authors and surrogate outcomes; not evidence that pantothenic acid has the same effects or that events or mortality improve. Different effect size from the 2011 trial is not automatically a mechanistic conflict.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The smaller trial also found lower LDL, under its own study conditions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b5-clin-evans2014] Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation. (2014). https://pubmed.ncbi.nlm.nih.gov/24600231/ DOI: 10.2147/vhrm.s57116","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Circulating lipids","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a0d70fcd-9b4f-5e88-830b-def535301c6c","evidence_kind":"source_excerpt","locator":"Lines 1411-1423","start_line":1411,"end_line":1423,"excerpt":"### b5-clin-pantethine-ldl-2014\nThe 32-person trial reported LDL-C about 11% below baseline with pantethine at week 16 versus a 3% increase with placebo; the week-16 comparison was significant (P=0.006).\nCondition category: normal\nnutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The smaller trial also found lower LDL, under its own study conditions.\norganism: Homo sapiens\ntissue_or_cell_type: Circulating lipids\nexperimental_model: Randomized triple-blind placebo- and diet-controlled trial in 32 adults eligible for statin therapy under the study criteria\nlimitations: Small short trial with industry-associated authors and surrogate outcomes; not evidence that pantothenic acid has the same effects or that events or mortality improve. Different effect size from the 2011 trial is not automatically a mechanistic conflict.\nexposure: Pantethine 600 mg/day for weeks 1–8 and 900 mg/day for weeks 9–16.\ncross_nutrient: false\nevidence_location: Primary indexed abstract; full article retrieval was unavailable.\n[b5-clin-evans2014] Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation. (2014). https://pubmed.ncbi.nlm.nih.gov/24600231/ DOI: 10.2147/vhrm.s57116","model_system":"Randomized triple-blind placebo- and diet-controlled trial in 32 adults eligible for statin therapy under the study criteria","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b5-clin-evans2014] Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation. (2014). https://pubmed.ncbi.nlm.nih.gov/24600231/ DOI: 10.2147/vhrm.s57116","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0716b500-dd0b-5425-b9d0-d88bc9c09e86","stable_key":"import-f992b796-377d-53bf-a39b-7e5d41dbe194","title":"Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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