{"id":"f8c6fb95-37ee-5fe1-ac8b-a1d99ec9cd3a","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-hgp-psa-null","predicate":"did_not_meaningfully_change","statement":"No meaningful between-group PSA difference appeared after six months.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"1b6bf4cf-1f62-5963-9d3c-09aec36fd0fd","mechanism_event_label":"A prostate blood marker did not show a meaningful benefit.","subject":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"object":{"id":"7346b3ab-5d46-5cc1-b940-98aa68d647bf","slug":"serum-psa","display_name":"Serum prostate-specific antigen","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1b6bf4cf-1f62-5963-9d3c-09aec36fd0fd","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-hgp-psa-null-event","event_type":"biochemical_relationship","label":"A prostate blood marker did not show a meaningful benefit.","description":"No meaningful between-group PSA difference appeared after six months.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7346b3ab-5d46-5cc1-b940-98aa68d647bf","slug":"serum-psa","display_name":"Serum prostate-specific antigen","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lycopene-research/26422197.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1327af281ec573be44c88b10fc7973e82e4963aab7bef3f7d14122e6c2a3dbea\", \"start_char\": 0, \"end_char\": 1542, \"text_sha256\": \"1327af281ec573be44c88b10fc7973e82e4963aab7bef3f7d14122e6c2a3dbea\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized six-month repeat-biopsy trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Tomato extract containing 30 mg/day lycopene versus placebo","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small surrogate-endpoint study; exploratory histological extent findings were not established cancer prevention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lycopene research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human, 58 completers with high-grade prostatic intraepithelial neoplasia","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A prostate blood marker did not show a meaningful benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lycopene-p26422197] A Phase II Randomized Trial of Lycopene-Rich Tomato Extract Among Men with High-Grade Prostatic Intraepithelial Neoplasia. (2015). https://pubmed.ncbi.nlm.nih.gov/26422197/ DOI: 10.1080/01635581.2015.1075560","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Serum biomarkers and prostate biopsies","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3730e6fc-d8ed-5978-9075-2b2ef1331cae","evidence_kind":"source_excerpt","locator":"Lines 1131-1142","start_line":1131,"end_line":1142,"excerpt":"### lycopene-hgp-psa-null\nNo meaningful between-group PSA difference appeared after six months.\nCondition category: normal\nnutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A prostate blood marker did not show a meaningful benefit.\norganism: Human, 58 completers with high-grade prostatic intraepithelial neoplasia\ntissue_or_cell_type: Serum biomarkers and prostate biopsies\nexperimental_model: Randomized six-month repeat-biopsy trial\nlimitations: Small surrogate-endpoint study; exploratory histological extent findings were not established cancer prevention.\nexposure: Tomato extract containing 30 mg/day lycopene versus placebo\nevidence_span: {\"source_cache\": \"artifacts/lycopene-research/26422197.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1327af281ec573be44c88b10fc7973e82e4963aab7bef3f7d14122e6c2a3dbea\", \"start_char\": 0, \"end_char\": 1542, \"text_sha256\": \"1327af281ec573be44c88b10fc7973e82e4963aab7bef3f7d14122e6c2a3dbea\"}\n[lycopene-p26422197] A Phase II Randomized Trial of Lycopene-Rich Tomato Extract Among Men with High-Grade Prostatic Intraepithelial Neoplasia. 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