{"id":"f8ad8a7e-59a9-588e-81ab-c1f297c50723","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-year-fat","predicate":"reduces_trial_measure","statement":"At one year, body fat mass was lower than placebo in CLA-triglyceride and free-fatty-acid groups by 8.7% and 6.9%, respectively.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"672322a6-dd7a-5b5e-b2e5-64a8ef8801a7","mechanism_event_label":"A longer mixed-preparation trial found a body-composition effect.","subject":{"id":"6f0cf7bd-c6e5-52d1-92f8-dd5c879e3c57","slug":"cla-mixed-isomer-preparations","display_name":"Study-specific mixed-isomer CLA preparations","entity_type_key":"chemical_species"},"object":{"id":"40bb29d3-3656-556d-a376-12fb22e0c20a","slug":"human-cla-trial-fat-mass","display_name":"Human body fat mass in CLA trials","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"672322a6-dd7a-5b5e-b2e5-64a8ef8801a7","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-year-fat-event","event_type":"observed_relationship","label":"A longer mixed-preparation trial found a body-composition effect.","description":"At one year, body fat mass was lower than placebo in CLA-triglyceride and free-fatty-acid groups by 8.7% and 6.9%, respectively.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6f0cf7bd-c6e5-52d1-92f8-dd5c879e3c57","slug":"cla-mixed-isomer-preparations","display_name":"Study-specific mixed-isomer CLA preparations","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"40bb29d3-3656-556d-a376-12fb22e0c20a","slug":"human-cla-trial-fat-mass","display_name":"Human body fat mass in CLA trials","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"180 overweight adults randomized to two formulations or olive oil.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"These are fat-mass comparisons, not percentage-point body-fat changes or proven disease prevention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A longer mixed-preparation trial found a body-composition effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15159244/ · DOI 10.1093/ajcn/79.6.1118","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"818dbe4c-b310-581c-87b6-bcbe10a9739b","evidence_kind":"source_excerpt","locator":"Lines 454-460","start_line":454,"end_line":460,"excerpt":"## cla-year-fat\nA longer mixed-preparation trial found a body-composition effect.\nAt one year, body fat mass was lower than placebo in CLA-triglyceride and free-fatty-acid groups by 8.7% and 6.9%, respectively.\nModel: 180 overweight adults randomized to two formulations or olive oil.\nLimitations: These are fat-mass comparisons, not percentage-point body-fat changes or proven disease prevention.\nEvidence access: Primary abstract\nConjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15159244/ · DOI 10.1093/ajcn/79.6.1118","model_system":"180 overweight adults randomized to two formulations or olive oil.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"f9fe73a8a4008d52061c65abe6de7a9806da75f1c478c5adace9387b8ffaad9e","revision_id":"21196d9c-aaab-5fe1-8f32-2987c94289c6","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}