{"id":"f87012ac-6f16-5a51-8d1d-40b0efdc3230","stable_key":"d8050016-13c9-5391-9d61-63de73590053:zeaxanthin-human-meso-null","predicate":"does_not_form_detectably_in_assay","statement":"No meso-zeaxanthin formation was detected over the trial sampling period.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e5d3d010-3226-51e2-ac6d-1f1c8ba2d98c","mechanism_event_label":"The study did not show rapid conversion of dietary zeaxanthin into meso-zeaxanthin.","subject":{"id":"0a60c685-7502-5ece-9da2-2c1a2e3bcdf1","slug":"zeaxanthin","display_name":"Dietary (3R,3-prime-R)-zeaxanthin","entity_type_key":"small_molecule"},"object":{"id":"24cea833-2dbe-5746-be4d-06b3b7c6315c","slug":"meso-zeaxanthin","display_name":"meso-Zeaxanthin / (3R,3-prime-S)-zeaxanthin","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"e5d3d010-3226-51e2-ac6d-1f1c8ba2d98c","stable_key":"d8050016-13c9-5391-9d61-63de73590053:zeaxanthin-human-meso-null-event","event_type":"observed_intervention","label":"The study did not show rapid conversion of dietary zeaxanthin into meso-zeaxanthin.","description":"No meso-zeaxanthin formation was detected over the trial sampling period.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0a60c685-7502-5ece-9da2-2c1a2e3bcdf1","slug":"zeaxanthin","display_name":"Dietary (3R,3-prime-R)-zeaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"24cea833-2dbe-5746-be4d-06b3b7c6315c","slug":"meso-zeaxanthin","display_name":"meso-Zeaxanthin / (3R,3-prime-S)-zeaxanthin","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zeaxanthin-research/15137922.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6410a0f5d52cf32390f90f59a7b17d2340a889f888836129f8a93482ca055be0\", \"start_char\": 0, \"end_char\": 1847, \"text_sha256\": \"6410a0f5d52cf32390f90f59a7b17d2340a889f888836129f8a93482ca055be0\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized single-blind crossover meal trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"5 mg free zeaxanthin equivalents as free pigment or dipalmitate in yoghurt/breakfast; 24 h sampling","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Meal- and formulation-specific response; no proof of disease prevention or an optimal universal formulation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zeaxanthin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zeaxanthin","display_name":"Dietary (3R,3-prime-R)-zeaxanthin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"12 volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The study did not show rapid conversion of dietary zeaxanthin into meso-zeaxanthin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zeaxanthin-p15137922] Comparison of plasma responses in human subjects after the ingestion of 3R,3R'-zeaxanthin dipalmitate from wolfberry (Lycium barbarum) and non-esterified 3R,3R'-zeaxanthin using chiral high-performance liquid chromatography. (2004). https://pubmed.ncbi.nlm.nih.gov/15137922/ DOI: 10.1079/bjn20041105","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma response","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"89e99dc9-3668-592d-8147-94e855b91226","evidence_kind":"source_excerpt","locator":"Lines 808-819","start_line":808,"end_line":819,"excerpt":"### zeaxanthin-human-meso-null\nNo meso-zeaxanthin formation was detected over the trial sampling period.\nCondition category: normal\nnutrient_topic: Zeaxanthin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The study did not show rapid conversion of dietary zeaxanthin into meso-zeaxanthin.\norganism: 12 volunteers\ntissue_or_cell_type: Plasma response\nexperimental_model: Randomized single-blind crossover meal trial\nlimitations: Meal- and formulation-specific response; no proof of disease prevention or an optimal universal formulation.\nexposure: 5 mg free zeaxanthin equivalents as free pigment or dipalmitate in yoghurt/breakfast; 24 h sampling\nevidence_span: {\"source_cache\": \"artifacts/zeaxanthin-research/15137922.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6410a0f5d52cf32390f90f59a7b17d2340a889f888836129f8a93482ca055be0\", \"start_char\": 0, \"end_char\": 1847, \"text_sha256\": \"6410a0f5d52cf32390f90f59a7b17d2340a889f888836129f8a93482ca055be0\"}\n[zeaxanthin-p15137922] Comparison of plasma responses in human subjects after the ingestion of 3R,3R'-zeaxanthin dipalmitate from wolfberry (Lycium barbarum) and non-esterified 3R,3R'-zeaxanthin using chiral high-performance liquid chromatography. (2004). https://pubmed.ncbi.nlm.nih.gov/15137922/ DOI: 10.1079/bjn20041105","model_system":"Randomized single-blind crossover meal trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zeaxanthin-p15137922] Comparison of plasma responses in human subjects after the ingestion of 3R,3R'-zeaxanthin dipalmitate from wolfberry (Lycium barbarum) and non-esterified 3R,3R'-zeaxanthin using chiral high-performance liquid chromatography. 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