{"id":"f86f4537-a8cb-5610-a45e-b28511e3c998","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-absorption-not-identical","predicate":"has_different_fractional_absorption_than","statement":"In 17 patients with osteoporosis or chronic renal failure, mean six-hour fractional absorption was 20.2% for stable strontium versus 37.8% for calcium, despite correlated time courses.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a329576e-4b3e-5cbe-b16e-4b18c1bec79d","mechanism_event_label":"Strontium can be a calcium tracer surrogate without behaving identically.","subject":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"object":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"evidence_count":1,"mechanism_event":{"id":"a329576e-4b3e-5cbe-b16e-4b18c1bec79d","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-absorption-not-identical-event","event_type":"observed_relationship","label":"Strontium can be a calcium tracer surrogate without behaving identically.","description":"In 17 patients with osteoporosis or chronic renal failure, mean six-hour fractional absorption was 20.2% for stable strontium versus 37.8% for calcium, despite correlated time courses.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ca2864b-1ef0-54e4-8397-1dbe7207a0d2","slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"31bf058b-2152-5e0d-8191-acfbee9199c9","slug":"human-intestinal-strontium-absorption","display_name":"Human intestinal strontium absorption","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Consecutive-day dual-tracer tests with standardized meals; ten osteoporosis and seven renal-failure patients.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small selected sample; nonlinear relationship and meal/carrier doses matter. Accessed abstract is explicitly truncated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Strontium can be a calcium tracer surrogate without behaving identically.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Stable strontium absorption as a measure of intestinal calcium absorption: comparison with the double-radiotracer calcium absorption test. · 1994 · https://pubmed.ncbi.nlm.nih.gov/7955914/ · DOI 10.1042/cs0870363","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"583104f2-62e4-53af-8fc0-12ae636f9a33","evidence_kind":"source_excerpt","locator":"Lines 46-52","start_line":46,"end_line":52,"excerpt":"## strontium-absorption-not-identical\nStrontium can be a calcium tracer surrogate without behaving identically.\nIn 17 patients with osteoporosis or chronic renal failure, mean six-hour fractional absorption was 20.2% for stable strontium versus 37.8% for calcium, despite correlated time courses.\nModel: Consecutive-day dual-tracer tests with standardized meals; ten osteoporosis and seven renal-failure patients.\nLimitations: Small selected sample; nonlinear relationship and meal/carrier doses matter. Accessed abstract is explicitly truncated.\nEvidence access: Primary abstract\nStable strontium absorption as a measure of intestinal calcium absorption: comparison with the double-radiotracer calcium absorption test. · 1994 · https://pubmed.ncbi.nlm.nih.gov/7955914/ · DOI 10.1042/cs0870363","model_system":"Consecutive-day dual-tracer tests with standardized meals; ten osteoporosis and seven renal-failure patients.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"43ef0fe7-eb6c-5346-8381-f7694733b4dc","stable_key":"import-1ff3a29f-ef80-5bff-9300-30b98c60b90d","title":"Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"51221949263cdf8a22a79c32e3989599de1a37dc215700e0a076f436b40a1005","revision_id":"84f6df49-c456-5ad2-8214-cc69d5dc7722","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}