{"id":"f856dd22-0860-53b3-8464-c497be1edeb5","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-gpd2-quinol","predicate":"couples_substrate_oxidation_to_reduction_of","statement":"GPD2 coupled glycerol-3-phosphate oxidation to ubiquinol formation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"01adbc8f-58ac-5add-9776-d65dd95ffd27","mechanism_event_label":"Another metabolic input feeds the same reduced CoQ pool.","subject":{"id":"e3a468b0-08ac-57a3-8df4-942934b35b2a","slug":"gpd2","display_name":"Human mitochondrial glycerol-3-phosphate dehydrogenase / GPD2","entity_type_key":"protein"},"object":{"id":"ae9544c3-df78-54f8-80e7-5b643e5ba1cf","slug":"ubiquinone","display_name":"Ubiquinone","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"01adbc8f-58ac-5add-9776-d65dd95ffd27","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-gpd2-quinol-event","event_type":"biochemical_relationship","label":"Another metabolic input feeds the same reduced CoQ pool.","description":"GPD2 coupled glycerol-3-phosphate oxidation to ubiquinol formation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8fa86a09-88cc-5a0f-85d8-a87a7eed7925","slug":"glycerol-3-phosphate","display_name":"Glycerol 3-phosphate","entity_type_key":"small_molecule"},"role":"substrate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"64fbe9b3-bf24-5b66-9611-8b78262d6ffc","slug":"reduced-coq10","display_name":"Reduced CoQ10","entity_type_key":"small_molecule"},"role":"product","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e3a468b0-08ac-57a3-8df4-942934b35b2a","slug":"gpd2","display_name":"Human mitochondrial glycerol-3-phosphate dehydrogenase / GPD2","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"ae9544c3-df78-54f8-80e7-5b643e5ba1cf","slug":"ubiquinone","display_name":"Ubiquinone","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/coq10-research/35749365.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8d8219ff3cd63697715c88c25a9e558315bcd95c25bbc38f76987544bfee7581\", \"start_char\": 0, \"end_char\": 1142, \"text_sha256\": \"8d8219ff3cd63697715c88c25a9e558315bcd95c25bbc38f76987544bfee7581\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Metabolomics, genetic deletion and tumor experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"G3P supply and GPD2/GPX4 loss","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Preclinical mechanism; no evidence that glycerol or CoQ supplements treat cancer.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Cancer-cell and tumor models","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Another metabolic input feeds the same reduced CoQ pool.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[coq10-p35749365] A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria. (2022). https://pubmed.ncbi.nlm.nih.gov/35749365/ DOI: 10.1073/pnas.2121987119","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Mitochondrial glycerol-phosphate oxidation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b5a555f7-3ecd-5b37-86db-3f86cf160f31","evidence_kind":"source_excerpt","locator":"Lines 853-864","start_line":853,"end_line":864,"excerpt":"### coq10-gpd2-quinol\nGPD2 coupled glycerol-3-phosphate oxidation to ubiquinol formation.\nCondition category: normal\nnutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Another metabolic input feeds the same reduced CoQ pool.\norganism: Cancer-cell and tumor models\ntissue_or_cell_type: Mitochondrial glycerol-phosphate oxidation\nexperimental_model: Metabolomics, genetic deletion and tumor experiments\nlimitations: Preclinical mechanism; no evidence that glycerol or CoQ supplements treat cancer.\nexposure: G3P supply and GPD2/GPX4 loss\nevidence_span: {\"source_cache\": \"artifacts/coq10-research/35749365.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8d8219ff3cd63697715c88c25a9e558315bcd95c25bbc38f76987544bfee7581\", \"start_char\": 0, \"end_char\": 1142, \"text_sha256\": \"8d8219ff3cd63697715c88c25a9e558315bcd95c25bbc38f76987544bfee7581\"}\n[coq10-p35749365] A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria. 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