{"id":"f836900a-9bd6-56bb-a7c2-a1088def1d5b","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-diarrhea-duration","predicate":"reduced","statement":"Zinc reduced continued-diarrhea risk by 23% (95% CI 12–32%); the reduction was 7% (−9 to 22%) on days 1–3 and 38% (27–48%) thereafter. Starting within three days reduced episodes lasting over seven days by 39% (7–61%).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"388dde30-7151-5650-a8ba-5b7a4207054e","mechanism_event_label":"The zinc group recovered sooner, with differences depending on treatment timing.","subject":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"object":{"id":"65441385-8efe-5499-8a03-1b4d9c0ffaa4","slug":"child-diarrheal-illness-days","display_name":"Child diarrheal illness days","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"388dde30-7151-5650-a8ba-5b7a4207054e","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-diarrhea-duration-event","event_type":"observed_intervention","label":"The zinc group recovered sooner, with differences depending on treatment timing.","description":"Zinc reduced continued-diarrhea risk by 23% (95% CI 12–32%); the reduction was 7% (−9 to 22%) on days 1–3 and 38% (27–48%) thereafter. Starting within three days reduced episodes lasting over seven days by 39% (7–61%).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"65441385-8efe-5499-8a03-1b4d9c0ffaa4","slug":"child-diarrheal-illness-days","display_name":"Child diarrheal illness days","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Zinc exposure and the specifically measured response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Indexed primary abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zinc-clinical-sources/sazawal1995.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"8c21c0c3ec6dedca7f245298445dfe9f71d64ff618734cd66b0eac35952c5bc8\", \"utf8_bytes\": 2090}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Double-blind randomized controlled trial in 937 children aged 6–35 months in New Delhi","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"20 mg elemental zinc/day; all children received oral rehydration and vitamin supplements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not every child had confirmed zinc deficiency. Specific zinc salt is not verified from abstract; efficacy belongs to this regimen and background care.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The zinc group recovered sooner, with differences depending on treatment timing.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zn-clin-sazawal1995] Zinc supplementation in young children with acute diarrhea in India. (1995). https://pubmed.ncbi.nlm.nih.gov/7651474/ DOI: 10.1056/nejm199509283331304","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Acute diarrheal illness","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"bbe9663c-cfc9-5c61-acd0-2028e4065fbb","evidence_kind":"source_excerpt","locator":"Lines 1482-1495","start_line":1482,"end_line":1495,"excerpt":"### zn-clin-diarrhea-duration\nZinc reduced continued-diarrhea risk by 23% (95% CI 12–32%); the reduction was 7% (−9 to 22%) on days 1–3 and 38% (27–48%) thereafter. Starting within three days reduced episodes lasting over seven days by 39% (7–61%).\nCondition category: normal\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The zinc group recovered sooner, with differences depending on treatment timing.\norganism: Homo sapiens\ntissue_or_cell_type: Acute diarrheal illness\nexperimental_model: Double-blind randomized controlled trial in 937 children aged 6–35 months in New Delhi\nlimitations: Not every child had confirmed zinc deficiency. Specific zinc salt is not verified from abstract; efficacy belongs to this regimen and background care.\nexposure: 20 mg elemental zinc/day; all children received oral rehydration and vitamin supplements.\ncross_nutrient: Zinc exposure and the specifically measured response.\nevidence_location: Indexed primary abstract.\nevidence_span: {\"source_cache\": \"artifacts/zinc-clinical-sources/sazawal1995.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"8c21c0c3ec6dedca7f245298445dfe9f71d64ff618734cd66b0eac35952c5bc8\", \"utf8_bytes\": 2090}\n[zn-clin-sazawal1995] Zinc supplementation in young children with acute diarrhea in India. (1995). https://pubmed.ncbi.nlm.nih.gov/7651474/ DOI: 10.1056/nejm199509283331304","model_system":"Double-blind randomized controlled trial in 937 children aged 6–35 months in New Delhi","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zn-clin-sazawal1995] Zinc supplementation in young children with acute diarrhea in India. (1995). https://pubmed.ncbi.nlm.nih.gov/7651474/ DOI: 10.1056/nejm199509283331304","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c5ee0fee-ce5c-58de-905a-10fb0ea0723c","stable_key":"import-6d38d43e-01e4-5641-93be-65654271e242","title":"Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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